V4515

VU0238429

solubility: ≥20 mg/mL in DMSO

• Synonym(e): 1-[(4-Methoxyphenyl)methyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione
• Empirische Formel (Hill-System): C₁₇H₁₂F₃NO₄
• CAS-Nummer: 1160247-92-6
• Molekulargewicht: 351.28
• MDL-Nummer: MFCD16618396
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329829052
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Qualitätsniveau: 100
• Form: powder
• Farbe: orange
• Löslichkeit: DMSO: ≥20 mg/mL
• Lagertemp.: 2-8°C
• SMILES String: COc1ccc(CN2C(=O)C(=O)c3cc(OC(F)(F)F)ccc23)cc1
• InChI: 1S/C17H12F3NO4/c1-24-11-4-2-10(3-5-11)9-21-14-7-6-12(25-17(18,19)20)8-13(14)15(22)16(21)23/h2-8H,9H2,1H3
• InChIKey: CKLGZXFOLMHCMC-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

VU0238429 is a selective muscarinic acetylcholine receptor 5 (M5) positive allosteric modulator; causes leftward shift in acetylcholine potency. M5 is thought to regulate cerebral blood flow, and activation of M5 may be therapeutic for Alzheimer′s disease. VU0238429 is the first reported M5-selective small molecule of any kind. It is >30-fold more selective for M5 over M1, M2, M3, and M4.

Leistungsmerkmale und Vorteile

This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Piktogramme: GHS07,GHS09
• Signalwort: Warning
• H-Sätze: H319,H400
• P-Sätze: P264 - P273 - P280 - P305 + P351 + P338 - P337 + P313 - P391
• Gefahreneinstufungen: Aquatic Acute 1 - Eye Irrit. 2
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable