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UC282

Sigma-Aldrich

6β-Hydroxytestosterone

≥97% (HPLC)

Synonym(e):

4-Androstene-6β,17β-diol-3-one, 6β, 17β,-Dihydroxyandrost-4-en-3-one

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About This Item

Empirische Formel (Hill-System):
C19H28O3
CAS-Nummer:
62-99-7
Molekulargewicht:
304.42
MDL-Nummer:
MFCD00171612
UNSPSC-Code:
12161501
PubChem Substanz-ID:
24900687

Assay

≥97% (HPLC)

Arzneimittelkontrolle

regulated under CDSA - not available from Sigma-Aldrich Canada

Farbe

white to off-white

mp (Schmelzpunkt)

≥205 °C

Löslichkeit

acetonitrile: soluble
ethanol: soluble
methanol: soluble

Lagertemp.

2-8°C

SMILES String

C[C@]12CC[C@H]3[C@@H](C[C@@H](O)C4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O

InChI

1S/C19H28O3/c1-18-7-5-11(20)9-15(18)16(21)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,12-14,16-17,21-22H,3-8,10H2,1-2H3/t12-,13-,14-,16+,17-,18+,19-/m0/s1

InChIKey

XSEGWEUVSZRCBC-ZVBLRVHNSA-N

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Anwendung

6β-Hydroxytestosterone has been used for CYP3A activity assays in rat hepatocytes and has also been used for CYP3A4 substrate selection studies.

Biochem./physiol. Wirkung

6β-Hydroxytestosterone is a CYP3A4 metabolite; androgenic.

Angaben zur Herstellung

6β-Hydroxytestosterone is soluble in methanol, acetonitrile and ethanol.

Ersetzt durch

Produkt-Nr.
Beschreibung
Preisangaben

H2898

6β-Hydroxytestosterone, ≥97% (HPLC)

Piktogramme

Health hazard
GHS08

Signalwort

Danger

H-Sätze

H351,H360

Gefahreneinstufungen

Carc. 2 - Repr. 1B

Lagerklassenschlüssel

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

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Analysenzertifikate (COA)

Lot/Batch Number
068K3351
037K3851

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Die Dokumentenbibliothek aufrufen

Aleksandra Galetin et al.
The Journal of pharmacology and experimental therapeutics, 314(1), 180-190 (2005-03-24)
The complexity of in vitro kinetic phenomena observed for CYP3A4 substrates (homo- or heterotropic cooperativity) confounds the prediction of drug-drug interactions, and an evaluation of alternative and/or pragmatic approaches and substrates is needed. The current study focused on the utility
Yoshitaka Miyamoto et al.
Cell transplantation, 18(5), 677-681 (2009-09-25)
Three-dimensional culture procedures have attracted attention in various fields of cell biology. A newly developed cell array assisted in the formation of hepatocyte spheroids by two innovations: 1) micropatterning by a hydrophilic polymer, and 2) the use of bovine carotid
Dan A Rock et al.
Drug metabolism and disposition: the biological fate of chemicals, 36(12), 2410-2413 (2008-09-04)
Cytochrome P450 (P450) reaction phenotyping is a key process toward accurately determining the contribution of different P450s to the metabolism of new chemical entities. The significance of P450s to drug disposition has led to the identification of selective chemical and
Cuiping Chen et al.
The Journal of pharmacology and experimental therapeutics, 300(2), 417-420 (2002-01-24)
The adrenochrome reaction (oxidation of epinephrine to adrenochrome) has been widely employed as a standard assay for reactive oxygen species, produced under a variety of conditions, including those produced during cytochrome P450 (CYP)-mediated oxidation of substrates such as cyclosporine. However
Yong Liu et al.
Biological & pharmaceutical bulletin, 27(10), 1555-1560 (2004-10-07)
The intestinal bacterial metabolites of ginsenosides are responsible for the main pharmacological activities of ginseng. The purpose of this study was to find whether these metabolites influence hepatic metabolic enzymes and to predict the potential for ginseng-prescription drug interactions. Utilizing
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