H2898

6β-Hydroxytestosterone

≥97% (HPLC), testosterone metabolite, powder

• Synonym(e): 4-Androstene-6β,17β-diol-3-one, 6β, 17β,-Dihydroxyandrost-4-en-3-one
• Empirische Formel (Hill-System): C₁₉H₂₈O₃
• CAS-Nummer: 62-99-7
• Molekulargewicht: 304.42
• UNSPSC Code: 12352200
• PubChem Substance ID: 24895541
• NACRES: NA.77
• MDL number: MFCD00171612
• Assay: ≥97% (HPLC)
• Form: powder

Eigenschaften

• Produktname: 6β-Hydroxytestosterone, ≥97% (HPLC)
• sterility: non-sterile
• Quality Segment: 200
• assay: ≥97% (HPLC)
• form: powder
• drug control: regulated under CDSA - not available from Sigma-Aldrich Canada
• solubility: methanol: 50 mg/mL, clear, colorless
• shipped in: ambient
• storage temp.: room temp
• SMILES string: C[C@]12CC[C@H]3[C@@H](C[C@@H](O)C4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2O
• InChI: 1S/C19H28O3/c1-18-7-5-11(20)9-15(18)16(21)10-12-13-3-4-17(22)19(13,2)8-6-14(12)18/h9,12-14,16-17,21-22H,3-8,10H2,1-2H3/t12-,13-,14-,16+,17-,18+,19-/m0/s1
• InChI key: XSEGWEUVSZRCBC-ZVBLRVHNSA-N

Beschreibung

Application

6β-Hydroxytestosterone has been used as a standard in high-performance liquid chromatography (HPLC) analysis to measure testosterone 6 β -hydroxylase activity in rat liver microsomes, and measure cytochrome P450 3A (CYP3A) activity in the intestinal spheroid model.

Biochem/physiol Actions

6β-Hydroxytestosterone is a CYP3A4 metabolite; androgenic.

6β-Hydroxytestosterone is a metabolite generated by brain testosterone cytochrome P450 1B1 (CYP1B1). It may elicit angiotensin II-induced neurogenic hypertension and inflammation in male mice.

Sicherheitshinweise

• pictograms: GHS08
• signalword: Danger
• hcodes: H351,H360
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 2 - Repr. 1B
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges