T7189

Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

• MDL-Nummer: MFCD02689206
• UNSPSC-Code: 51111800
• NACRES: NA.32

Eigenschaften

• Biologische Quelle: human
• Qualitätsniveau: 200
• Rekombinant: expressed in NSO cells
• Assay: >95% (SDS-PAGE)
• Form: lyophilized powder
• Wirksamkeit: 0.004-0.016 mg per mL ED₅₀
• Mol-Gew.: 52.6 kDa
• Verpackung: pkg of 50 μg
• Lagerbedingungen: avoid repeated freeze/thaw cycles
• Methode(n): cell culture | mammalian: suitable
• Verunreinigungen: endotoxin, tested
• UniProt-Hinterlegungsnummer: P20333
• Lagertemp.: −20°C
• Angaben zum Gen: human ... TNFRSF1B(7133)

Beschreibung

Anwendung

Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human can be used as a test compound for analyzing the interaction between tumor necrosis factor (TNF) and its two soluble receptors by using surface plasmon resonance (SPR) technique.

Biochem./physiol. Wirkung

Tumor Necrosis Factor Soluble Receptor II (TNF sRII)/Fc Chimera human belongs to TNF family of receptors and mediates the metabolic effects of TNF-α. Tumor Necrosis Factor Soluble Receptor II blocks the TNF-α-induced apoptosis and hence regulates the TNF-α function. It also has a pivotal role in neutralizing the biological activities of both TNF-α and TNF-β.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline

Hinweis zur Analyse

The biological activity is measured by its ability to neutralize the TNF-α mediated cytotoxicity in mouse L-929 cells in the presence of the metabolic inhibitor actinomycin D.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable