SRP3146
Prokineticin-2 human
recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC), suitable for cell culture
Synonym(e):
PK2, PROK2, Protein Bv8 homolog
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About This Item
UNSPSC-Code:
12352200
NACRES:
NA.32
Empfohlene Produkte
Biologische Quelle
human
Rekombinant
expressed in E. coli
Assay
≥98% (HPLC)
≥98% (SDS-PAGE)
Form
lyophilized
Mol-Gew.
8.8 kDa
Verpackung
pkg of 20 μg
Methode(n)
cell culture | mammalian: suitable
Verunreinigungen
<0.1 EU/μg endotoxin, tested
Farbe
white
UniProt-Hinterlegungsnummer
Versandbedingung
wet ice
Lagertemp.
−20°C
Angaben zum Gen
human ... PROK2(60675)
Allgemeine Beschreibung
Prokineticin-2 (PK2) is a cysteine-rich secreted protein that is expressed in the testis and in lower levels of the small intestine. PK2 regulates various biological functions including gastrointestinal motility, angiogenesis and circadiam rhythms. It is closely related to EG-VEGF (Prokineticin-1) and binds to two orphan B-protein-coupled receptors termed PK-R1 and PK-R2. Recombinant human Prokineticin-2 is an 8.8 kDa protein consisting of 81 amino acid residues and ten cysteine residues that potentially form five intra-molecular disulfide bonds.It also contains completely conserved N-terminal hexapeptide sequence that is involved in biological activity. PK2 is encoded by the gene mapped to human chromosome 3p13.
Biochem./physiol. Wirkung
Prokineticin-2 (PK2) plays a vital role in regulation of various biological functions, such as gastrointestinal motility, angiogenesis and circadian rhythms. It is closely related to EG-VEGF (endocrine gland-derived vascular endothelial growth factor)/prokineticin-1 (PK1). PK1 and PK2 exert their function by interacting with two G protein-coupled receptors PKR1 and PKR2, respectively. PK2 is a candidate gene for the pathogenesis of mood disorders.
Sequenz
AVITGACDKD SQCGGGMCCA VSIWVKSIRI CTPMGKLGDS CHPLTRKVPF FGRRMHHTCP CLPGLACLRT SFNRFICLAQ K
Physikalische Form
Lyophilized with no additives.
Rekonstituierung
Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/ml. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.
Lagerklassenschlüssel
11 - Combustible Solids
WGK
WGK 3
Flammpunkt (°F)
Not applicable
Flammpunkt (°C)
Not applicable
Analysenzertifikate (COA)
Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.
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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.
Possible association of prokineticin 2 receptor gene (PROKR2) with mood disorders in the Japanese population.
Kishi T, et al.
Neuromolecular Medicine, 11(2), 114-122 (2009)
Prokineticin 2 and circadian clock output.
Zhou Q Y and Cheng M Y
FEBS Journal, 272(22), 5703-5709 (2005)
The prokineticins: a novel pair of regulatory peptides.
Zhou Q Y.
Molecular Interventions, 6(6), 330-330 (2006)
Takatoshi Soga et al.
Biochimica et biophysica acta, 1579(2-3), 173-179 (2002-11-13)
Recent studies have identified two novel biofunctional proteins, termed prokineticin 1/EG-VEGF and prokineticin 2, which were mammalian homologues of mamba MIT1 and frog Bv8. Prokineticins have been demonstrated to exert their physiological functions through G-protein coupled receptors (GPCRs). In this
Oualid Sbai et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 28(8), 3734-3744 (2014-05-17)
Various missense mutations in the gene coding for prokineticin receptor 2 (PROKR2), a G-protein-coupled receptor, have been identified in patients with Kallmann syndrome. However, the functional consequences of these mutations on the different signaling pathways of this receptor have not
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