Direkt zum Inhalt
Merck

SRP0254

Sigma-Aldrich

Cofilin 1 Active human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

Synonym(e):

CFL1, Cofilin, non-muscle isoform, p18

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About This Item

UNSPSC-Code:
12352202
NACRES:
NA.32

Biologische Quelle

human

Rekombinant

expressed in E. coli

Assay

≥90% (SDS-PAGE)

Form

aqueous solution

Mol-Gew.

44 kDa

Verpackung

pkg of 200 μg

Konzentration

>0.02 mg/mL

NCBI-Hinterlegungsnummer

UniProt-Hinterlegungsnummer

Versandbedingung

dry ice

Lagertemp.

−70°C

Angaben zum Gen

human ... CFL1(1072)

Allgemeine Beschreibung

Cofilin 1 is ubiquitously expressed and has a molecular mass of ~19kDa.
Human recombinant Cofilin1 (2-end) with N-terminal GST tag (GenBank Accession No. NM_005507), expressed in a E. coli expression system. Cofilin 1, MW = 44 kDa,
Human recombinant Cofilin1 (2-end) with N-terminal GST tag (GenBank Accession No. NM_005507), expressed in a E. coli expression system. Cofilin 1, MW = 44 kDa,

Anwendung

Kinase substrate for the kinase assay; western blot

Biochem./physiol. Wirkung

Cofilin-l (CFL1) plays a vital role in the regulation of actin cytoskeleton reorganization. It is also implicated in cancer cell migration and invasion in several types of tumor tissues. Elevated expression of the gene is associated with the development of esophageal squamous cell carcinoma (ESCC). In addition, abnormal expression of the gene leads to vulvar cancer and thus, it can be considered as a potential therapeutic target for the same. CFL1 facilitates cytokinesis, cell motility and morphogenesis. Activated CFL1 helps in preventing cytoskeletal-associated defects in axonal development stimulated by Syns.

Physikalische Form

Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol and 3 mM DTT.

Angaben zur Herstellung

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 1

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


Analysenzertifikate (COA)

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In der Dokumentenbibliothek finden Sie die Dokumentation zu den Produkten, die Sie kürzlich erworben haben.

Die Dokumentenbibliothek aufrufen

The role of cofilin-l in vulvar squamous cell carcinoma: A marker of carcinogenesis, progression and targeted therapy.
Wu Q
Oncology Reports, 35, 2743-2754 (2016)
Cofilin 1 activation prevents the defects in axon elongation and guidance induced by extracellular alpha-synuclein.
Tilve S
Scientific Reports (2015)

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