SML2963

8-Azaguanin

≥98% (HPLC)

• Synonym(e): 2-Amino-6-hydroxy-8-azapurin, Guanazolo
• Empirische Formel (Hill-System): C₄H₄N₆O
• CAS-Nummer: 134-58-7
• Molekulargewicht: 152.11
• Beilstein: 171098
• MDL-Nummer: MFCD00056937
• UNSPSC-Code: 12352200

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• mp (Schmelzpunkt): >300 °C (lit.)
• Löslichkeit: DMSO: 2 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: NC1=Nc2[nH]nnc2C(=O)N1
• InChI: 1S/C4H4N6O/c5-4-6-2-1(3(11)7-4)8-10-9-2/h(H4,5,6,7,8,9,10,11)
• InChIKey: LPXQRXLUHJKZIE-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

8-Azaguanine is a triazole-antimetabolite that displays varies pharmacological effects including anticancer, antiviral and antifungal. It is easily incorporated into ribonucleic acids including rRNA and tRNA. 8-Azaguanine appears to alter mRNA splicing in SF3B1 mutant cells. 8-Azaguanine novel immunomodulatory drug (IMiD) that significantly increases the cytotoxicity of NK cells.

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302
• P-Sätze: P264 - P270 - P301 + P312 - P501
• Gefahreneinstufungen: Acute Tox. 4 Oral
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable