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A4660

Sigma-Aldrich

6-Thioguanin

Hybri-Max™, 50 ×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma

Synonym(e):

2-Amino-6-mercapto-purin, 2-Amino-6-purinthiol

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About This Item

Empirische Formel (Hill-System):
C5H5N5S
CAS-Nummer:
154-42-7
Molekulargewicht:
167.19
Beilstein:
157765
EG-Nummer:
205-827-2
MDL-Nummer:
MFCD00233553
UNSPSC-Code:
12352207
PubChem Substanz-ID:
24890892
NACRES:
NA.75

Biologische Quelle

synthetic (organic)

Qualitätsniveau

200

Qualität

Hybri-Max™

Sterilität

γ-irradiated

Produktlinie

BioXtra

Assay

~98%

Form

lyophilized powder

Konzentration

50 ×

Methode(n)

cell culture | hybridoma: suitable

Verunreinigungen

endotoxin, tested

mp (Schmelzpunkt)

≥300 °C (lit.)

Löslichkeit

1 M NaOH: 50 mg/mL, clear to slightly hazy

Lagertemp.

room temp

SMILES String

NC1=Nc2nc[nH]c2C(=S)N1

InChI

1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)

InChIKey

WYWHKKSPHMUBEB-UHFFFAOYSA-N

Angaben zum Gen

human ... IMPDH1(3614) , IMPDH2(3615)

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Verwandte Kategorien

Anwendung

Used in hybridoma formation applications as a selection agent.

Biochem./physiol. Wirkung

Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.

Rekonstituierung

Reconstitute contents of vial with 10 ml sterile cell culture medium. Stock solution is sufficient to prepare 500 ml medium. Final working concentration: 30 μM 2-amino-6-mercaptopurine.

Rechtliche Hinweise

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301

P-Sätze

P301 + P310

Gefahreneinstufungen

Acute Tox. 3 Oral

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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HT-Medien-Supplement (50×) Hybri-Max™ lyophilized powder, γ-irradiated, BioXtra, suitable for hybridoma

Sigma-Aldrich

H0137

HT-Medien-Supplement (50×) Hybri-Max™

Polyethylenglycol-/Dimethylsulfoxid-Lösung Hybri-Max™, average mol wt 1,450, 50 % (w/v), 0.2 μm filtered, BioReagent, suitable for hybridoma

Sigma-Aldrich

P7306

Polyethylenglycol-/Dimethylsulfoxid-Lösung

Tioguanin British Pharmacopoeia (BP) Reference Standard

BP878

Tioguanin

Donghui Li et al.
Nucleic acids research, 49(5), 2642-2654 (2021-02-17)
The CRISPR/Cas9 system is a technology for genome engineering, which has been applied to indel mutations in genes as well as targeted gene deletion and replacement. Here, we describe paired gRNA deletions along the PIGA locus on the human X
N K H de Boer et al.
Digestion, 73(1), 25-31 (2006-02-24)
Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004, European experts applying
Quentin Gueranger et al.
The Journal of investigative dermatology, 134(5), 1408-1417 (2013-11-29)
Damage to skin DNA by solar UV is largely unavoidable, and an optimal cellular response to it requires the coordinated operation of proteins in numerous pathways. A fully functional DNA repair proteome for removing harmful DNA lesions is a prerequisite
Nanne K H de Boer et al.
European journal of gastroenterology & hepatology, 17(4), 457-461 (2005-03-10)
The use of corticosteroids in autoimmune hepatitis is an established therapy. To avoid the possible serious side effects of corticosteroids, immunosuppression with azathioprine is often warranted. Azathioprine, a purine analogue, is frequently used to taper or replace corticosteroids. However, approximately
Reto Brem et al.
Cancer research, 72(18), 4787-4795 (2012-07-24)
The thiopurines azathioprine and 6-mercaptopurine have been extensively prescribed as immunosuppressant and anticancer agents for several decades. A third member of the thiopurine family, 6-thioguanine (6-TG), has been used less widely. Although known to be partly dependent on DNA mismatch
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