SML2560

OB-1

≥98% (HPLC)

• Synonym(e): Ethyl 5-(1-methyl-4-nitro-1H-imidazol-5-yloxy)-2-phenylbenzofuran-3-carboxylate
• Empirische Formel (Hill-System): C₂₁H₁₇N₃O₆
• CAS-Nummer: 300803-69-4
• Molekulargewicht: 407.38
• MDL-Nummer: MFCD01462999
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to very dark brown
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: 2-8°C
• SMILES String: [N+](=O)([O-])c1nc[n](c1Oc2cc3c([o]c(c3C(=O)OCC)c4ccccc4)cc2)C
• InChIKey: UJHGRDVYTTVJFD-UHFFFAOYSA-N

Beschreibung

Biochem./physiol. Wirkung

Inhibitor of Stomatin-like protein-3 (STOML3) oligomerization

OB-1 is an inhibitor of the oligomerization of Stomatin-like protein-3 (STOML3), which is a modulator of the mechanosensitive ion channel Piezo2. STOML3 requires oligomerization for its role as an endogenous regulator of the sensitivity of mechanosensitive Piezo ion channels in sensory neurons. By inhibiting this activity, OB-1 has been shown to reduce touch-evoked pain behavior in two mouse models of neuropathic pain.

Sicherheitshinweise

• Lagerklassenschlüssel: 13 - Non Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable