J4455

JSH-23

≥98% (HPLC), NF-kB nuclear translocation inhibitor, solid

• Synonym(e): 4-methyl-N1-(3-phenylpropyl)-1,2-benzenediamine
• Empirische Formel (Hill-System): C₁₆H₂₀N₂
• CAS-Nummer: 749886-87-1
• Molekulargewicht: 240.34
• UNSPSC Code: 51111800
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: solid
• Storage condition: protect from light

Eigenschaften

• Produktname: JSH-23, ≥98% (HPLC), solid
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: solid
• storage condition: protect from light
• color: off-white to gray-pink
• solubility: DMSO: >10 mg/mL
• shipped in: wet ice
• storage temp.: −20°C
• SMILES string: N(CCCc2ccccc2)c1c(cc(cc1)C)N
• InChI: 1S/C16H20N2/c1-13-9-10-16(15(17)12-13)18-11-5-8-14-6-3-2-4-7-14/h2-4,6-7,9-10,12,18H,5,8,11,17H2,1H3
• InChI key: YMFNPBSZFWXMAD-UHFFFAOYSA-N

Beschreibung

Application

JSH-23 has been used as a nuclear factor κB (NF-κB) p65 inhibitor.[1][2]

Biochem/physiol Actions

JSH-23 is an inhibitor of NF-kB nuclear translocation.

JSH-23 is an inhibitor of NF-kB nuclear translocation. It inhibits LPS and cytokine-induced nuclear translocation of the p65 subunit of NF-kB as analyzed by EMSA and western blot. The compound displays modest potency (IC50 7.1 uM in RAW 264.7), but has the unique property that it does not affect IkB degradation or recovery. The compound dose dependently inhibits LPS induced expression of cytokines, COX2 and iNOS, and presumably binds to, or interferes with the NLS of p65.

Other Notes

Light and air sensitive.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• pictograms: GHS07
• signalword: Warning
• hcodes: H302,H317
• pcodes: P261 - P264 - P272 - P280 - P301 + P312 - P302 + P352
• Hazard Classifications: Acute Tox. 4 Oral - Skin Sens. 1B