SML2124

Ned-K

≥98% (HPLC)

• Synonym(e): (1R,3S)-1-(3-((4-(2-Cyanophenyl)piperazin-1-yl)methyl)-4-methoxyphenyl)-2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole-3-carboxylic acid
• Empirische Formel (Hill-System): C₃₁H₃₁N₅O₃
• CAS-Nummer: 2250019-90-8
• Molekulargewicht: 521.61
• MDL-Nummer: MFCD30742938
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 2 mg/mL, clear
• Lagertemp.: −20°C

Beschreibung

Biochem./physiol. Wirkung

Ned-K is a specific and potent inhibitor of NAADP (nicotinic acid adenine dinucleotide phosphate) signaling that suppresses Ca²⁺ oscillations via two-pore channels (TPC1) and opening of the mitochondrial permeability transition pore (mPTP) in cardiomyocytes during simulated ischaemia and reperfusion. Ned-K protected cardiomyocytes from cell death during ischaemia and reperfusion injury in rats.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable