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SML1455

Sigma-Aldrich

DAA-I acetate salt

≥98% (HPLC)

Synonym(e):

5-L-Isoleucine-2-10-Angiotensin I acetate salt, Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu acetate, RVYIHPFHL acetate, [Des-Asp1-Ile5]angiotensin I, des-Asp-angiotensin I acetate, des-aspartate-angiotensin-I acetate

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About This Item

Empirische Formel (Hill-System):
C58H84N16O11 · xC2H4O2
CAS-Nummer:
Molekulargewicht:
1181.39 (free base basis)
UNSPSC-Code:
12352200
NACRES:
NA.77

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Qualitätsniveau

Assay

≥98% (HPLC)

Form

film

Farbe

colorless

Versandbedingung

wet ice

Lagertemp.

−20°C

Biochem./physiol. Wirkung

DAA-I (des-aspartate-angiotensin-I) is an agonist on the angiotensin AT1 receptor and releases prostaglandins which mediate its actions. DAA-I administer at doses lesser than Km of metabolizing enzymes antagonize the deleterious actions of angiotensin II. DAA-I appear function in vivo as a physiological antagonist to angiotensin II.
DAA-I (des-aspartate-angiotensin-I) is an agonist on the angiotensin AT1 receptor.
Des-aspartate-angiotensin I (DAA-I) is a nine-amino acid angiotensin peptide[1] and a metabolite of angiotensin[2] DAA-I mediates attenuation of early inflammatory processes[1] and intercellular adhesion molecule-1 (ICAM-1) formation in animal models.[3]

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable


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Yong-Chiat Wong et al.
Biochemical pharmacology, 82(9), 1198-1208 (2011-08-02)
Although clinical studies suggested that blockade of the renin-angiotensin system may prevent diabetes, the mechanism is uncertain. As a follow-up to an earlier study, we investigated how des-aspartate-angiotensin-1 (DAA-1) and its metabolite, angiotensin IV (Ang-IV) improved glucose tolerance in diet-induced
Meng-Kwoon Sim
European journal of pharmacology, 760, 36-41 (2015-04-22)
The review describes DAA-I (des-aspartate-angiotensin-I) as a prototype of a novel class of drugs that acts as agonists on the angiotensin AT1 receptor or ARAs (angiotensin receptor agonists). DAA-I is a component of the renin angiotensin system. Earlier studies showed
Qiang Wen et al.
European journal of pharmacology, 658(2-3), 193-199 (2011-03-05)
The present study investigated the actions of des-aspartate-angiotensin I (DAA-I) on infarct size and three early inflammatory events in acute myocardial ischemia-reperfusion injury in rats. The rationale was based on earlier findings showing that chronic daily administration of DAA-I attenuated
Abd Jalil Rufaihah et al.
Life sciences, 78(12), 1341-1351 (2006-01-21)
We investigate the influence of des-Aspartate-angiotensin-I (DAA-I) on the cytokine expression profile in a rodent model of myocardial infarction. Myocardial infarction model was created in female Wistar rats by coronary artery ligation. Animals were randomized to receive intravenously either a
M Dharmani et al.
Regulatory peptides, 129(1-3), 213-219 (2005-06-02)
The present study investigated the action of des-aspartate-angiotensin I (DAA-I) on the pressor action of angiotensin II in the renal and mesenteric vasculature of WKY, SHR and streptozotocin (STZ)-induced diabetic rats. Angiotensin II-induced a dose-dependent pressor response in the renal

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