SML1224

Torin2

≥98% (HPLC)

• Synonym(e): 9-(6-Amino-3-pyridinyl)-1-[3-(trifluoromethyl)phenyl]-benzo[h]-1,6-naphthyridin-2(1H)-one
• Empirische Formel (Hill-System): C₂₄H₁₅F₃N₄O
• CAS-Nummer: 1223001-51-1
• Molekulargewicht: 432.40
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to beige
• Löslichkeit: DMSO: 5 mg/mL, clear (warmed)
• Lagertemp.: 2-8°C
• SMILES String: FC(F)(F)c1cc(ccc1)[n]2c3c4c(ncc3cc[c]2=O)ccc(c4)c5cnc(cc5)N
• InChI: 1S/C24H15F3N4O/c25-24(26,27)17-2-1-3-18(11-17)31-22(32)9-6-16-13-29-20-7-4-14(10-19(20)23(16)31)15-5-8-21(28)30-12-15/h1-13H,(H2,28,30)
• InChIKey: GUXXEUUYCAYESJ-UHFFFAOYSA-N

Beschreibung

Anwendung

Torin2 has been used:

• to examine its effect on LC3B-II levels in BORCS5- KO cells[1]
• to determine its potent activity (IC₅₀ less than 1 μM) against A2780-cis ovarian cancer cells[2]
• in western blot analysis[3]

Biochem./physiol. Wirkung

Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor.

Torin2 is a highly potent and selective ATP-competitive mTOR inhibitor. Torin2 has an IC₅₀ of 0.25 nM and 800-fold greater selectivity for mTOR than PI3K.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable