SML1158

(2S)-Hypusine dihydrochloride

≥95% (HPLC)

• Synonym(e): (+)-Hypusine dihydrochloride, N6-[(2RS)-4-Amino-2-hydroxybutyl]-L-lysine dihydrochloride
• Empirische Formel (Hill-System): C₁₀H₂₃N₃O₃ · 2HCl
• Molekulargewicht: 306.23
• UNSPSC-Code: 12352209
• PubChem Substanz-ID: 329825688
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥95% (HPLC)
• Form: powder
• Lagerbedingungen: desiccated
• Farbe: white to beige
• Löslichkeit: H₂O: 15 mg/mL, clear
• Lagertemp.: −20°C
• SMILES String: [H]Cl.[H]Cl.N[C@H](C(O)=O)CCCCNCC(O)CCN
• InChI: 1S/C10H23N3O3.2ClH/c11-5-4-8(14)7-13-6-2-1-3-9(12)10(15)16;;/h8-9,13-14H,1-7,11-12H2,(H,15,16);2*1H/t8?,9-;;/m0../s1
• InChIKey: UTSZZUVUESAPQD-AHBBCRTASA-N

Beschreibung

Biochem./physiol. Wirkung

(2S)-Hypusine is an unusual amino acid found only in eukaryotic translation initiation factor 5A (eIF5A) and a similar protein in archaebacteria. (2S)-Hypusine is formed by posttranslational modification of a lysine with the addition of the 4-aminobutyl moiety from the polyamine spermidine. There is increasing interest in the polyamine-hypusine axis and eIF5A, its a role in cell growth and differentiation, and a recent paper on the polyamine-hypusine axis as a potential new tumour suppressor network.

(2S)-Hypusine is an unusual amino acid found only in eukaryotic translation initiation factor 5A (eIF5A).

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable