S9882

Sulfachlorpyridazin

• Synonym(e): 4-Amino-N-(6-chlor-3-pyridazinyl)-benzolsulfonamid, N¹-(6-Chlor-3-pyridazinyl)-sulfanilamid
• Empirische Formel (Hill-System): C₁₀H₉ClN₄O₂S
• CAS-Nummer: 80-32-0
• Molekulargewicht: 284.72
• UNSPSC Code: 51102829
• NACRES: NA.85
• PubChem Substance ID: 24899860
• EC Number: 201-269-9
• Beilstein/REAXYS Number: 261558
• MDL number: MFCD00057371

Eigenschaften

• form: powder
• color: off-white to light yellow
• solubility: 0.5 M NaOH: soluble 50 mg/mL
• antibiotic activity spectrum: Gram-negative bacteria, Gram-positive bacteria, mycoplasma
• mode of action: DNA synthesis | interferes
• SMILES string: Nc1ccc(cc1)S(=O)(=O)Nc2ccc(Cl)nn2
• InChI: 1S/C10H9ClN4O2S/c11-9-5-6-10(14-13-9)15-18(16,17)8-3-1-7(12)2-4-8/h1-6H,12H2,(H,14,15)
• InChI key: XOXHILFPRYWFOD-UHFFFAOYSA-N

Beschreibung

Application

Sulfachloropyridazine is a sulfonamide antibiotic that is used to study kinetics, reaction pathways and toxicity evolution[1]. Sulfachloropyridazine has been used to treat acute urinary tract infections in pediatric patients[2].

Biochem/physiol Actions

Sulfachloropyridazine is a sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase. Sulfachloropyridazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), which is required for bacterial synthesis of folic acid[3]. It is active against Gram positive bacteria, Gram negative bacteria and Chlamydia. Mode of resistance is via the alteration of dihydropteroate synthase or alternative pathway for folic acid synthesis. Sulfachloropyridazine is rapidly absorbed and rapidly excreted in the urine.

Other Notes

Keep container tightly closed in a dry and well-ventilated place.

Sicherheitshinweise

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P280
• Hazard Classifications: Skin Sens. 1
• Lagerklasse: 13 - Non Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves