S8071

Salvinorin A

≥98% (HPLC), solid

• Synonym(e): (2S,4aR,6aR,7R,9S,10aS,10bR)-9-(acetyloxy)-2-(3-furanyl)dodechydro-6a,10b-dimethyl-4,10-dioxo-2H-naphtho[2,1-c]pyran-7-carboxylic acid methyl ester
• Empirische Formel (Hill-System): C₂₃H₂₈O₈
• CAS-Nummer: 83729-01-5
• Molekulargewicht: 432.46
• MDL-Nummer: MFCD05664742
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 24899776
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 100
• Assay: ≥98% (HPLC)
• Form: solid
• Arzneimittelkontrolle: regulated under CDSA - not available from Sigma-Aldrich Canada
• Lagerbedingungen: protect from light
• Farbe: white
• Löslichkeit: DMSO: ≥10 mg/mL; ethanol: ~3 mg/mL
• Lagertemp.: −20°C
• SMILES String: [H][C@@]12CC[C@@]3(C)[C@@H](C[C@H](OC(C)=O)C(=O)[C@]3([H])[C@@]1(C)C[C@H](OC2=O)c4ccoc4)C(=O)OC
• InChI: 1S/C23H28O8/c1-12(24)30-16-9-15(20(26)28-4)22(2)7-5-14-21(27)31-17(13-6-8-29-11-13)10-23(14,3)19(22)18(16)25/h6,8,11,14-17,19H,5,7,9-10H2,1-4H3/t14-,15-,16-,17-,19-,22-,23-/m0/s1
• InChIKey: OBSYBRPAKCASQB-AGQYDFLVSA-N
• Angaben zum Gen: human ... OPRD1(4985) , OPRK1(4986) , OPRM1(4988) ; rat ... Oprk1(29335)

Beschreibung

Anwendung

Salvinorin A was administered to rats to study effects on lactic acid-stimulated stretching.¹

Biochem./physiol. Wirkung

Salvanorin A is a non-nitrogenous κ opioid receptor agonist.

Salvinorin A is a potent, non-nitrogenous κ opioid selective receptor agonist. Salvinorin A is isolated from Salvia divinorum. Salvinorin A displays high affinity at both native (K_i=4.3 nm) and cloned (K_i=16 nm) κ -opioid receptors. Preliminary studies suggest that Salvanorin A is chemically unique among the psychtropic drugs and does not bind to any known receptor.

Leistungsmerkmale und Vorteile

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)