R8526

RO-52 (SSA) human

recombinant, expressed in E. coli, liquid

• Synonym(e): Anti-RO-52 antibody
• MDL-Nummer: MFCD03458409
• UNSPSC-Code: 12352202
• NACRES: NA.56

Eigenschaften

• Biologische Quelle: human
• Qualitätsniveau: 200
• Rekombinant: expressed in E. coli
• Form: liquid
• Mol-Gew.: 52 kDa by SDS-PAGE
• Methode(n): ELISA: suitable
• UniProt-Hinterlegungsnummer: P19474
• Lagertemp.: −70°C
• Angaben zum Gen: human ... TRIM21(6737)

Beschreibung

Allgemeine Beschreibung

Research area: Cell Signaling
RO-52 (SSA), also called as tripartite motif-containing protein 21 (TRIM21) is a 52 kDa, ubiquitin E3 ligase.[1] It has a N-terminal RING finger domain (Really Interesting New Gene), crucial for ubiquitination functionality.[2] RO-52 (SSA) gene is mapped to human chromosome 11p5.5.

Anwendung

RO-52 (SSA) human has been used:

• as a component of the autoantigen array[3]
• to immobilise protein on the self-assembly monolayer[4][5]
• in enzyme-linked immunosorbent assays (ELISAs)[6]

Biochem./physiol. Wirkung

RO-52 (SSA) is capable of autoubiquitination [7] and uniquitylates p62 protein and regulates redox homeostasis.[1]Patients with Sjogren′s syndrome display elevated levels of anti-Ro/SSA antibodies.[2] RO-52 levels in peripheral blood mononuclear cells (PBMC) contributes to pathogenesis of systemic lupus erythematosus (SLE)[8], systemic autoimmune rheumatic diseases (SARDs),[9] interstitial lung disease (ILD) and connective tissue diseases (CTD).[10] RO-52 is considered as potential target for treating SLE.[8]

Used for the detection and quantification of antibodies to RNPs in rheumatic diseases.

Physikalische Form

solution contains 20 mM phosphate buffer, 500 mM NaCl, 2M - 3M urea, pH 6.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 2
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable