N2286

Nonactin

from Streptomyces griseus, ≥98.0% (Total homologs, HPLC)

• Synonym(e): Ammonium-Ionophor
• Empirische Formel (Hill-System): C₄₀H₆₄O₁₂
• CAS-Nummer: 6833-84-7
• Molekulargewicht: 736.93
• Beilstein: 76434
• EG-Nummer: 229-911-3
• UNSPSC-Code: 51102829
• PubChem Substanz-ID: 24897566
• NACRES: NA.76

Eigenschaften

• Biologische Quelle: Streptomyces griseus
• Qualitätsniveau: 300
• Beschreibung: Natural macrotetrolide, may contain homologues (like monactin and dinactin)
• Assay: ≥98.0% (Total homologs, HPLC)
• Form: powder
• Löslichkeit: chloroform: soluble 10 mg/mL
• Wirkungsspektrum von Antibiotika: Gram-positive bacteria
• Wirkungsweise: DNA synthesis | interferes; cell membrane | interferes
• Lagertemp.: 2-8°C
• SMILES String: C[C@H]1C[C@@H]2CC[C@@H](O2)[C@@H](C)C(=O)O[C@H](C)C[C@H]3CC[C@H](O3)[C@H](C)C(=O)O[C@@H](C)C[C@@H]4CC[C@@H](O4)[C@@H](C)C(=O)O[C@H](C)C[C@H]5CC[C@H](O5)[C@H](C)C(=O)O1
• InChI: 1S/C40H64O12/c1-21-17-29-9-13-34(49-29)26(6)38(42)46-23(3)19-31-11-15-36(51-31)28(8)40(44)48-24(4)20-32-12-16-35(52-32)27(7)39(43)47-22(2)18-30-10-14-33(50-30)25(5)37(41)45-21/h21-36H,9-20H2,1-8H3/t21-,22+,23+,24-,25-,26+,27+,28-,29-,30+,31+,32-,33-,34+,35+,36-
• InChIKey: RMIXHJPMNBXMBU-QIIXEHPYSA-N

Beschreibung

Allgemeine Beschreibung

Chemical structure: macrolide

Anwendung

Nonactin is a macrotetrolide that forms complexes with alkali cations, such as potassium and sodium. Nonactin has been reported to inhibit the processing of cytoplasmic precursor proteins destined for the mitochondria. Nonactin is an uncoupler of oxidative phosphorylation [1].

Biochem./physiol. Wirkung

Nonactin is used as a neutral lipid membrane soluble ammonium (and potassium) ionophore, and to inhibit surface expression of certain heat shock proteins (HSP60) [2][3].

Sonstige Hinweise

Keep container tightly closed in a dry and well-ventilated place.Keep in a dry place.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)