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N2162

Sigma-Aldrich

NH125

≥98% (HPLC), solid

Synonym(e):

1-Benzyl-3-cetyl-2-methylimidazolium iodide

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5 MG
€ 349,00

€ 349,00

Voraussichtliches Versanddatum28. Mai 2025

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5 MG
€ 349,00

About This Item

Empirische Formel (Hill-System):
C27H45IN2
CAS-Nummer:
278603-08-0
Molekulargewicht:
524.56
MDL-Nummer:
MFCD07370143
UNSPSC-Code:
12352200
PubChem Substanz-ID:
329818598
NACRES:
NA.77

€ 349,00

Voraussichtliches Versanddatum28. Mai 2025

Qualitätsniveau

100

Assay

≥98% (HPLC)

Form

solid

Farbe

white to off-white

mp (Schmelzpunkt)

88.2-94.9 °C

Löslichkeit

DMSO: >20 mg/mL

Lagertemp.

−20°C

SMILES String

[I-].CCCCCCCCCCCCCCCC[n+]1ccn(Cc2ccccc2)c1C

InChI

1S/C27H45N2.HI/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-19-22-28-23-24-29(26(28)2)25-27-20-17-16-18-21-27;/h16-18,20-21,23-24H,3-15,19,22,25H2,1-2H3;1H/q+1;/p-1

InChIKey

RVWOHCBHAGBLLT-UHFFFAOYSA-M

Biochem./physiol. Wirkung

NH125 exhibits anti-proliferation activity against many cancer cells. It also exhibits antibacterial effects by inhibiting bacterial histidine protein kinase.[1]
NH125 is a novel plant histidine kinase inhibitor and selective mammalian eurkaryotic elongation factor-2 kinase (eEF-2K).

Verpackung

Packaged under nitrogen.

Hinweis zur Analyse

IC50 = 60 nM for eEF-2 kinase vs protein kinase C (IC50= 7.5 μM), protein kinase A (IC50= 80 μM), and calmodulin-dependent kinase II IC50 > 100 μM).

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

dust mask type N95 (US), Eyeshields, Gloves

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
0000176287
0000176287
0000056804
0000053795
048K4615

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Yuan-Yuan Zhao et al.
Drug design, development and therapy, 12, 2655-2663 (2018-09-15)
Our previous research showed that AKT inactivation via small molecule inhibitors did not induce significant apoptosis, but rather markedly increased autophagy in nasopharyngeal carcinoma (NPC). The purpose of the current study was to determine whether autophagy inhibition can enhance the
Chih-Hua Chang et al.
Neuropharmacology, 143, 95-105 (2018-09-24)
When faced with stressful conditions, people with a tendency toward impulsive aggression may suddenly hurt others. We have previously shown that the blockade of NMDA receptors (NMDARs) within the ventral hippocampus (VH) produces anti-aggressive effects. However, little is known about
Tao Ma et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(36), 12230-12238 (2014-09-05)
The AMP-activated protein kinase (AMPK) is a Ser/Thr kinase that is activated in response to low-energy states to coordinate multiple signaling pathways to maintain cellular energy homeostasis. Dysregulation of AMPK signaling has been observed in Alzheimer's disease (AD), which is
Tomoko Kodama et al.
The Journal of veterinary medical science, 81(1), 35-41 (2018-11-16)
Eukaryotic elongation factor 2 (eEF2) kinase (eEF2K) inhibits protein translation through the phosphorylation of its specific substrate, eEF2. We previously demonstrated that eEF2K expression increases in superior mesenteric artery from spontaneously hypertensive rats (SHR) and that eEF2K mediates development of
Saad Sheikh et al.
Molecular cancer research : MCR, 17(5), 1102-1114 (2019-01-16)
The high incidence of glioblastoma recurrence necessitates additional therapeutic strategies. Heterogeneous populations of cells, including glioma stem cells (GSC) have been implicated in disease recurrence. GSCs are able to survive irradiation and temozolomide (TMZ) treatment due to upregulation of DNA
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