N158

Naftopidil hydrochloride hydrate

Name: Naftopidil hydrochloride hydrate
Brand: SIGMA
Price: 236 EUR

solid

Synonym(e):

4-(2-Methoxyphenyl)-α-[(1-naphthalenyloxy)methyl]-1-piperazineethanol hydrochloride hydrate, KT-611

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25 MG

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Über diesen Artikel

Empirische Formel (Hill-System):

C₂₄H₂₈N₂O₃ · xHCl · yH₂O

CAS-Nummer:

57149-07-2

Molekulargewicht:

392.49 (anhydrous free base basis)

NACRES:

NA.77

PubChem Substance ID:

24277790

UNSPSC Code:

12352200

MDL number:

MFCD11046013

Form:

solid

Quality level:

200

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Unterstützung erhalten

form

solid

Quality Level

200

color

white

solubility

methanol: >10 mg/mL, H₂O: insoluble

SMILES string

O.Cl.COc1ccccc1N2CCN(CC2)CC(O)COc3cccc4ccccc34

InChI

1S/C24H28N2O3.ClH.H2O/c1-28-24-11-5-4-10-22(24)26-15-13-25(14-16-26)17-20(27)18-29-23-12-6-8-19-7-2-3-9-21(19)23;;/h2-12,20,27H,13-18H2,1H3;1H;1H2

InChI key

INIDYCYXDNFBSV-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)

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Dieser Artikel	H4413	UC168	C6022
Sigma-Aldrich N158 Naftopidil hydrochloride hydrate	Sigma-Aldrich H4413 Hydroxyfasudil hydrochloride hydrate	Sigma-Aldrich UC168 (±)-Bufuralol hydrochloride	Sigma-Aldrich C6022 Cyproheptadine hydrochloride sesquihydrate
form solid	form solid	form solid	form solid
Quality Level 200	Quality Level 100	Quality Level 200	Quality Level 200
solubility methanol: >10 mg/mL, H₂O: insoluble	solubility H₂O: >5 mg/mL	solubility H₂O: soluble, methanol: soluble	solubility ethanol: soluble, methanol: soluble
color white	color white	color white to off-white	color white to slightly yellow
Gene Information human ... ADRA1A(148), ADRA1B(147), ADRA1D(146)	Gene Information -	Gene Information -	Gene Information human ... HRH1(3269), HTR2A(3356), HTR2B(3357), HTR2C(3358)

Biochem/physiol Actions

α₁-Adrenoceptor antagonist; antihypertensive.

Lagerklasse

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Determination of naftopidil enantiomers in rat plasma using chiral solid phases and pre-column derivatization high-performance liquid chromatography.

Xiawen Liu et al.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 907, 140-145 (2012-10-03)

Two bioanalytical HPLC methods (chiral solid phases (CSPs) HPLC and pre-column derivatization HPLC) were developed and validated for the determination of naftopidil enantiomers in rat plasma. Analytes were extracted from biomaterials by liquid-liquid extraction. The pre-column derivatization HPLC method employed

Effect of naftopidil, an alpha1D/A-adrenoceptor antagonist, on the urinary bladder in rats with spinal cord injury.

Katsumi Kadekawa et al.

Life sciences, 92(20-21), 1024-1028 (2013-04-16)

Alpha1D-adrenoceptors (α1D-ARs) located in the spinal cord are involved in the control of lower urinary tract function. In order to clarify the effect of α1D-ARs on storage function in the spinal cord, we examined the effect of oral administration and

Predictive factors for the effect of the α1-D/A adrenoceptor antagonist naftopidil on subjective and objective criteria in patients with neurogenic lower urinary tract dysfunction.

Masayuki Takeda et al.

BJU international, 108(1), 100-107 (2010-11-11)

• To assess the effect of α1-D/A adrenoceptor antagonist naftopidil on patients with neurogenic lower urinary tract dysfunction (NLUTD) and voiding difficulty. • To explore the effectiveness of naftopidil in these patients by using urodynamic variables, including pressure flow study

Analysis of energy loss mediated by an alpha-1 blocker in patients with benign prostatic hyperplasia using a virtual urethra processed from an endoscopic video image.

Tomokazu Sazuka et al.

Journal of endourology, 26(9), 1216-1220 (2012-04-11)

To examine the efficacy of an alpha-1 blocker and its correlation to structural alteration of the prostatic urethra and the loss of energy in the urine flow using a virtual urethra processed from an endoscopic video image. Video images of

Comparison of the effects of four α1-adrenoceptor antagonists on ejaculatory function in rats.

Satoshi Tatemichi et al.

Urology, 80(2), 486-486 (2012-06-09)

To compare the effects of four α(1)-adrenoceptor (AR) subtype-selective antagonists on ejaculatory function in rats to investigate whether the differences in their modes of action-based on their selectivities for the α(1A)-AR subtype-would be related to the prevalence of ejaculation disorder

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Global Trade Item Number

SKU	GTIN
N158-100MG	04061832092218
N158-25MG	04061832092225

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Naftopidil hydrochloride hydrate