C6022

Cyproheptadine hydrochloride sesquihydrate

≥98% (TLC), solid

• Synonym(e): Piperidine, 4-(5H-dibenzo[a,d]cyclohepten-5-ylidene)-1-methyl-, hydrochloride, hydrate (2:3)
• Empirische Formel (Hill-System): C₂₁H₂₁N·HCl·1.5H₂O
• CAS-Nummer: 41354-29-4
• Molekulargewicht: 350.88
• MDL number: MFCD00012538
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278082
• EC Number: 213-535-1
• NACRES: NA.77
• Assay: ≥98% (TLC)
• Form: solid
• Quality level: 200

Eigenschaften

• InChI: 1S/2C21H21N.2ClH.3H2O/c2*1-22-14-12-18(13-15-22)21-19-8-4-2-6-16(19)10-11-17-7-3-5-9-20(17)21;;;;;/h2*2-11H,12-15H2,1H3;2*1H;3*1H2
• InChI key: ZEAUHIZSRUAMQG-UHFFFAOYSA-N
• SMILES string: Cl.CN1CCC(\CC1)=C2/c3ccccc3C=Cc4ccccc24
• assay: ≥98% (TLC)
• form: solid
• color: white to slightly yellow
• solubility: ethanol: soluble, methanol: soluble
• originator: Merck & Co., Inc., Kenilworth, NJ, U.S.
• Quality Level: 200
• Gene Information: human ... HRH1(3269), HTR2A(3356), HTR2B(3357), HTR2C(3358)

Beschreibung

Application

Cyproheptadine hydrochloride sesquihydrate has been used in:

• testing anti-inflammatory activity in serotonin receptor (5-HT) induced inflammation[1]
• the inhibition of 5-HT in in vivo and in vitro bioassays in crabs[2]
• the inhibition of 5-HT in embryo physiological experiments[3]

inhibition of calcitonin gene related peptide (CGRP)[4]

Biochem/physiol Actions

Cyproheptadine hydrochloride sesquihydrate is a serotonin receptor (5-HT2/5-HT1C) antagonist,[5] H1 histamine receptor antagonist[6] and an antipruritic.[7] The inhibition of 5-HT by cyproheptadine improves cognitive function in schizophrenia disorder.[5] Cyproheptadine is effective for treating functional gastrointestinal disorders (FGIDs).[8] Food and Drug Administration (FDA) approved cyproheptadine, has antidepressant and antiplatelet functionality. It may be effective in treating thromboembolic disorders.[9] Cyproheptadine inhibits lysine methyltransferase 7/9 (Set7/9) leading to a decrease in estrogen receptor (ERα) expression and growth arrest in breast cancer cells.[10]

Features and Benefits

This compound was developed by Merck & Co., Inc., Kenilworth, NJ, U.S.. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• pictograms: GHS06
• signalword: Danger
• hcodes: H301,H315,H319,H335
• pcodes: P261 - P264 - P271 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Lagerklasse: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• wgk: WGK 3
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves