M212

Mastoparan-7

≥97% (HPLC), lyophilized powder

• Synonym(e): Mas 7
• Empirische Formel (Hill-System): C₆₇H₁₂₄N₁₈O₁₅
• CAS-Nummer: 145854-59-7
• Molekulargewicht: 1421.81
• MDL-Nummer: MFCD00144726
• UNSPSC-Code: 41106300
• PubChem Substanz-ID: 329817929
• NACRES: NA.77

Eigenschaften

• Qualitätsniveau: 200
• Assay: ≥97% (HPLC)
• Form: lyophilized powder
• Lagertemp.: −20°C
• SMILES String: CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O
• InChI: 1S/C67H124N18O15/c1-18-38(12)53(71)67(100)85-51(32-52(70)86)66(99)84-50(31-37(10)11)64(97)79-45(24-20-22-26-69)61(94)75-42(16)58(91)82-47(28-34(4)5)62(95)76-39(13)55(88)73-40(14)57(90)81-48(29-35(6)7)63(96)77-41(15)56(89)78-44(23-19-21-25-68)60(93)74-43(17)59(92)83-49(30-36(8)9)65(98)80-46(54(72)87)27-33(2)3/h33-51,53H,18-32,68-69,71H2,1-17H3,(H2,70,86)(H2,72,87)(H,73,88)(H,74,93)(H,75,94)(H,76,95)(H,77,96)(H,78,89)(H,79,97)(H,80,98)(H,81,90)(H,82,91)(H,83,92)(H,84,99)(H,85,100)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,53-/m0/s1
• InChIKey: HOLQXBRPSSZJMZ-FGRXCANLSA-N

Beschreibung

Amino Acid Sequence

Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Ala-Leu-Leu-NH2

Allgemeine Beschreibung

Mastoparan-7 is an analog of the mastoparan peptide. It is present in the venom of Vespula lewisii. It was originally isolated from wasp venom.

Anwendung

Mastoparan-7 has been used to study mastoparan-stimulated nucleotide binding to G proteins.

Biochem./physiol. Wirkung

Mastoparan-7 (Mas-7) stimulates the G protein subunit Gα_o/i by its mode of action (to bind to the plasma membrane). It possesses antiviral activity and is associated with histamine release from mast cells. It is also involved in the induction of potent mitochondrial permeability and tumor cell cytotoxicity.

Hinweis zur Analyse

More potent analog of mastoparan.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type N95 (US)