M212

Mastoparan-7

≥97% (HPLC), lyophilized powder

• Synonym(e): Mas 7
• Empirische Formel (Hill-System): C₆₇H₁₂₄N₁₈O₁₅
• CAS-Nummer: 145854-59-7
• Molekulargewicht: 1421.81
• NACRES: NA.77
• PubChem Substance ID: 329817929
• UNSPSC Code: 41106300
• MDL number: MFCD00144726
• Assay: ≥97% (HPLC)
• Form: lyophilized powder

Eigenschaften

• Quality Segment: 200
• assay: ≥97% (HPLC)
• form: lyophilized powder
• storage temp.: −20°C
• SMILES string: CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(N)=O
• InChI: 1S/C67H124N18O15/c1-18-38(12)53(71)67(100)85-51(32-52(70)86)66(99)84-50(31-37(10)11)64(97)79-45(24-20-22-26-69)61(94)75-42(16)58(91)82-47(28-34(4)5)62(95)76-39(13)55(88)73-40(14)57(90)81-48(29-35(6)7)63(96)77-41(15)56(89)78-44(23-19-21-25-68)60(93)74-43(17)59(92)83-49(30-36(8)9)65(98)80-46(54(72)87)27-33(2)3/h33-51,53H,18-32,68-69,71H2,1-17H3,(H2,70,86)(H2,72,87)(H,73,88)(H,74,93)(H,75,94)(H,76,95)(H,77,96)(H,78,89)(H,79,97)(H,80,98)(H,81,90)(H,82,91)(H,83,92)(H,84,99)(H,85,100)/t38-,39-,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,53-/m0/s1
• InChI key: HOLQXBRPSSZJMZ-FGRXCANLSA-N

Beschreibung

General description

Mastoparan-7 is an analog of the mastoparan peptide. It is present in the venom of Vespula lewisii. It was originally isolated from wasp venom.[1]

Application

Mastoparan-7 has been used to study mastoparan-stimulated nucleotide binding to G proteins.[2]

Biochem/physiol Actions

Mastoparan-7 (Mas-7) stimulates the G protein subunit Gα_o/i by its mode of action (to bind to the plasma membrane). It possesses antiviral activity and is associated with histamine release from mast cells. It is also involved in the induction of potent mitochondrial permeability and tumor cell cytotoxicity.[1]

Analysis Note

More potent analog of mastoparan.

Sicherheitshinweise

• Lagerklasse: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)