I2273

3-Indolacrylsäure

≥98% (HPLC), BioReagent

• Synonym(e): 3-(3-Indolyl)-acrylsäure
• Empirische Formel (Hill-System): C₁₁H₉NO₂
• CAS-Nummer: 1204-06-4
• Molekulargewicht: 187.19
• Beilstein: 6317
• EG-Nummer: 214-872-7
• MDL-Nummer: MFCD00005633
• UNSPSC-Code: 12352106
• PubChem Substanz-ID: 24895972
• NACRES: NA.52

Eigenschaften

• Qualität: for molecular biology
• Qualitätsniveau: 100
• Produktlinie: BioReagent
• Assay: ≥98% (HPLC)
• Form: powder
• Mol-Gew.: 187.19 g/mol
• Lagertemp.: room temp
• SMILES String: OC(=O)\C=C\c1c[nH]c2ccccc12
• InChI: 1S/C11H9NO2/c13-11(14)6-5-8-7-12-10-4-2-1-3-9(8)10/h1-7,12H,(H,13,14)/b6-5+
• InChIKey: PLVPPLCLBIEYEA-AATRIKPKSA-N

Beschreibung

Allgemeine Beschreibung

3-Indoleacrylic acid (IAA) is a chemical used for the induction of gene transcription. This expression system requires that the gene of interest is cloned in plasmids containing the trpE promoter.

Anwendung

3-Indoleacrylic acid has been used in the induction of ribokinase expression in E. coli.[1]

Biochem./physiol. Wirkung

3-Indoleacrylic acid (IAA) is metabolized from tryptophan and this conversion is carried out by gut microflora.[2] 3-Indoleacrylic acid (IAA) is a chemical used for the induction of gene transcription.[3] The IAA induced expression system requires the gene of interest cloned in plasmids containing the trp promoter.[3] It promotes the barrier functionality of the intestinal epithelial cells. IAA also favors anti-inflammatory response and is regarded as a potential therapeutic to treat inflammatory bowel disease (IBD).[4] It is also implicated in a variety of cellular processes including apoptosis, autophagy, cell proliferation and migration. In tumor cells, IAA is also reported to hinder tryptophan metabolism. [5]

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H315,H319,H335
• P-Sätze: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Gloves