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I0144

Sigma-Aldrich

Indolicidin

≥97% (HPLC)

Synonym(e):

Ile-Leu-Pro-Trp-Lys-Trp-Pro-Trp-Trp-Pro-Trp-Arg-Arg-NH2

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About This Item

Empirische Formel (Hill-System):
C100H132N26O13
CAS-Nummer:
140896-21-5
Molekulargewicht:
1906.28
UNSPSC-Code:
12352200

Assay

≥97% (HPLC)

Lagertemp.

−20°C

SMILES String

CC[C@H](C)[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc2c[nH]c3ccccc23)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc4c[nH]c5ccccc45)C(=O)N6CCC[C@H]6C(=O)N[C@@H](Cc7c[nH]c8ccccc78)C(=O)N[C@@H](Cc9c[nH]c%10ccccc9%10)C(=O)N%11CCC[C@H]%11C(=O)N[C@@H](Cc%12c[nH]c%13ccccc%12%13)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(N)=O

Allgemeine Beschreibung

Chemical structure: peptide

Biochem./physiol. Wirkung

Exhibits potent antimicrobial activity in vitro against bacteria and fungi.

Lagerklassenschlüssel

13 - Non Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

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J Kovacs-Nolan et al.
The Journal of general virology, 90(Pt 8), 1892-1905 (2009-04-24)
Respiratory syncytial virus (RSV) is the leading cause of serious respiratory tract disease in children and calves; however, RSV vaccine development has been slow due to early observations that formalin-inactivated vaccines induced Th2-type immune responses and led to disease enhancement
Linda Tomasinsig et al.
Infection and immunity, 78(4), 1781-1788 (2010-01-27)
Cathelicidins are peptide components of the innate immune system of mammals. Apart from exerting a direct antibiotic activity, they can also trigger specific defense responses in the host. Their roles in various pathophysiological conditions have been studied, but there is
Tatyana I Rokitskaya et al.
Biochimica et biophysica acta, 1808(1), 91-97 (2010-09-21)
Indolicidin, a 13-residue cationic peptide with extremely high tryptophan content, exhibits broad-spectrum antimicrobial as well as hemolytic activity. To gain insight into the mechanism of indolicidin action on membrane permeability, liposome leakage induced by this peptide was studied by using
A Pompilio et al.
Peptides, 32(9), 1807-1814 (2011-08-19)
Six different cathelicidin-derived peptides were compared to tobramycin for antibacterial and anti-biofilm effects against S. aureus, P. aeruginosa, and S. maltophilia strains isolated from cystic fibrosis patients. Overall, SMAP-29, BMAP-28, and BMAP-27 showed relevant antibacterial activity (MIC(50) 4-8μg/ml), and in
Yong Hai Nan et al.
Peptides, 30(5), 832-838 (2009-05-12)
Indolicidin (IN) is a 13-residue Trp-rich antimicrobial peptide isolated from bovine neutrophils. To develop novel IN-derived antimicrobial peptides with enhanced cell specificity (therapeutic index) and potent anti-inflammatory activity, several IN analogs were synthesized by Pro-->Lys substitution. All IN analogs displayed
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