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H6166

Sigma-Aldrich

Interferon α 2B human

IFN-α 2B, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture

Synonym(e):

IFN α 2B, IFN Alfa 2b, INF α 2B, INF Alfa 2b, Interferon Alfa 2b

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About This Item

MDL-Nummer:
MFCD01773210
UNSPSC-Code:
12352202
NACRES:
NA.77

Biologische Quelle

human

Qualitätsniveau

100

Rekombinant

expressed in HEK 293 cells

Assay

≥95% (SDS-PAGE)

Form

lyophilized powder

Wirksamkeit

≤0.12 ng/mL EC50

Qualität

endotoxin tested

Mol-Gew.

dimer 16 kDa (glycosylated)

Verpackung

poly bottle of 10 μg (in poly bottle)

Hersteller/Markenname

HumanZyme

Methode(n)

cell culture | mammalian: suitable

Verunreinigungen

≤1EU/mg

UniProt-Hinterlegungsnummer

P01563

Lagertemp.

−20°C

Angaben zum Gen

human ... IFNA2(3440)

Verwandte Kategorien

Allgemeine Beschreibung

The interferon α 2 (IFN-α2) exists in three forms 2a, 2b and 2c. It consists of 165 amino acids and five α helices. IFN-α2B is found structurally stable at pH 7. The recombinant IFN-α is nonglycosylated compared to the natural human IFN-α.

Biochem./physiol. Wirkung

Interferon α 2B (IFN-α 2B) belongs to the type I interferon protein family. It is produced by many cell types in response to viral infection. IFN-α 2B has antiproliferative and antitumor activities, as well as induction of apoptosis and the inflammatory response. It enhances the expression of MHC proteins by increasing the presentation of antigen peptides and activates cytotoxic T-cells.

Physikalische Form

Lyophilized from a 0.2 μm filtered solution of 1x PBS.

Angaben zur Herstellung

HumanKine IFN-α 2B is a glycosylated monomer expressed in HEK 293 cells with an apparent molecular mass of 16 kDa. Production in human 293 cells offers authentic glycosylation. Glycosylation contributes to stability in cell growth media and other applications.

Hinweis zur Analyse

The specific activity was determined by the dose-dependent proliferation of WISH (heteroploid human amnion cell line) in presence of VSV ( vesicular stomatitis virus).

Rechtliche Hinweise

HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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Sigma-Aldrich

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