G0295

Anti-GABA_A Receptor (α6 subunit), Cytosolic Loop antibody produced in rabbit

affinity isolated antibody, buffered aqueous glycerol solution

• Synonym(e): Anti-γ-Aminobutyric Acid Type A Receptor (α6 subunit)
• MDL-Nummer: MFCD07370321
• UNSPSC-Code: 12352203
• NACRES: NA.41

Eigenschaften

• Biologische Quelle: rabbit
• Qualitätsniveau: 200
• Konjugat: unconjugated
• Antikörperform: affinity isolated antibody
• Antikörper-Produkttyp: primary antibodies
• Klon: polyclonal
• Form: buffered aqueous glycerol solution
• Verwendung: sufficient for 10 blots
• Speziesreaktivität: rat
• Methode(n): western blot: 1:1000 using rat brain membrane fraction.
• UniProt-Hinterlegungsnummer: P30191
• Versandbedingung: wet ice
• Lagertemp.: −20°C
• Posttranslationale Modifikation Target: unmodified
• Angaben zum Gen: rat ... Gabra6(29708)

Beschreibung

Allgemeine Beschreibung

γ -aminobutyric acid (GABA) receptor is the multifunctional, pentameric membrane proteins that operate GABA-gated chloride channels. It acts as major inhibitory neurotransmitter in the adult mammalian brain. It is the members of the neurotransmitter ligand-gated ion channels which plays various functions in the central nervous system, the peripheral nervous system, and in some nonneuronal tissues. At least four types of subunits (α, β, γ and δ) of GABA have been identified. Generally it contains one type of α and β subunit, and a single γ polypeptide in a ratio of 2:2:1.

Immunogen

fusion protein with the amino acid sequence representing the cytosolic loop of the rat GABA_A receptor (α6 subunit)

Anwendung

Anti-GABA_A Receptor (α6 subunit), cytosolic loop antibody is suitable for western blot at a dilution of 1:1,000 using rat brain membrane fraction.

Biochem./physiol. Wirkung

GABA is synthesized primarily from glutamate by glutamate decarboxylase (GAD). It is triggered by binding to its ligand-gated chloride channels, GABA(A) and GABA(C) as well as metabotropic receptor GABA(B). Along with neural development, it is also involved in a wide variety of physiological functions in tissues and organs outside the brain.

Zielbeschreibung

Detects 56-57 kDa GABA_A receptor α6 subunit in rat brain membrane fractions.

Physikalische Form

Solution in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/ml BSA and 50% glycerol.

Haftungsausschluss

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Sicherheitshinweise

• Lagerklassenschlüssel: 10 - Combustible liquids
• WGK: WGK 1