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F6807

Sigma-Aldrich

Fleroxacin

Synonym(e):

6,8-Difluor-1-(2-fluorethyl)-1,4-dihydro-7-(4-methylpiperazino)-4-oxo-3-chinolincarbonsäure, 6,8-Difluor-1-(2-fluorethyl)1,4-dihydro-7-(4-methyl-1-piperazinyl)-4-oxo-3-chinolincarbonsäure, AM-833, Megalocin, Megalon

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About This Item

Empirische Formel (Hill-System):
C17H18F3N3O3
CAS-Nummer:
79660-72-3
Molekulargewicht:
369.34
MDL-Nummer:
MFCD00864880
UNSPSC-Code:
51102829
PubChem Substanz-ID:
329799758
NACRES:
NA.85

Assay

≥98% (HPLC)

Form

solid

Farbe

white to off-white

Löslichkeit

0.1 M NaOH: 10 mg/mL

Wirkungsspektrum von Antibiotika

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma

Wirkungsweise

DNA synthesis | interferes
enzyme | inhibits

Lagertemp.

−20°C

SMILES String

CN1CCN(CC1)c2c(F)cc3C(=O)C(=CN(CCF)c3c2F)C(O)=O

InChI

1S/C17H18F3N3O3/c1-21-4-6-22(7-5-21)15-12(19)8-10-14(13(15)20)23(3-2-18)9-11(16(10)24)17(25)26/h8-9H,2-7H2,1H3,(H,25,26)

InChIKey

XBJBPGROQZJDOJ-UHFFFAOYSA-N

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Anwendung

Fleroxacin is a broad-spectrum antimicrobial fluoroquinolone. It is used in pharmacokinetic studies and is used to study the treatment of intra-abdominal abscesses and travellers′ diarrhea.

Biochem./physiol. Wirkung

Fleroxacin is a synthetic trifluorinated quinolone with antimicrobial activity against a variety of pathogens, including mycobacteria, mycoplasmas, chlamydiae, and legionellae. It strongly inhibits the DNA-supercoiling activity of DNA gyrase and DNA topoisomerase 2, which results in cell death.

Lagerklassenschlüssel

11 - Combustible Solids

WGK

WGK 2

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Analysenzertifikate (COA)

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J C Akaniro et al.
Antimicrobial agents and chemotherapy, 34(10), 1880-1884 (1990-10-01)
We evaluated fleroxacin, a newer fluoroquinolone, against isolates from sputum from patients with cystic fibrosis. These isolates included rough and mucoid Pseudomonas aeruginosa, Pseudomonas cepacia, Staphylococcus aureus, Haemophilus influenzae, and Escherichia coli. Selected isolates were tested by the broth microdilution
R Steffen et al.
The Journal of antimicrobial chemotherapy, 31(5), 767-776 (1993-05-01)
A double-blind, randomized, placebo-controlled trial was conducted to evaluate the efficacy and safety of fleroxacin for one or two days as treatment for patients with travellers' diarrhoea. A total of 195 patients who were suffering with acute diarrhoea of less
A Pefanis et al.
Antimicrobial agents and chemotherapy, 38(2), 252-255 (1994-02-01)
To assess the potential efficacy of fleroxacin in combination with clindamycin or metronidazole in mixed aerobic and anaerobic infections, we used a rat model of intra-abdominal abscesses in which the inoculum consisted of pooled rat feces mixed with BaSO4. Two
R A Blouin et al.
Antimicrobial agents and chemotherapy, 36(3), 632-638 (1992-03-01)
In this open-label study, the disposition of fleroxacin in liver disease in 12 healthy male volunteers, 6 male cirrhotics without ascites (group A), and 6 male cirrhotics with ascites (group B) was evaluated. Fleroxacin (400 mg) was administered orally and
Rui-qin Feng et al.
Guang pu xue yu guang pu fen xi = Guang pu, 25(9), 1468-1470 (2005-12-29)
Based on the complex formed by Zn2+ which can strengthen the relative fluorescence intensity of fleroxacin evidently, a novel photochemical fluorescence method was developed. The effects of the acidity, the concentration ratio of Zn2+ to fleroxacin, and the time for
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