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E5007

Supelco

Etonitazen -hydrochlorid

Synonym(e):

1-(Diethylaminoethyl)-2-(p-ethoxybenzyl)-5-nitro-benzimidazol

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About This Item

Empirische Formel (Hill-System):
C22H28N4O3 · HCl
CAS-Nummer:
2053-25-0
Molekulargewicht:
432.94
MDL-Nummer:
MFCD00274575
UNSPSC-Code:
41116107
PubChem Substanz-ID:
329799064
NACRES:
NA.24

Qualität

analytical standard

Arzneimittelkontrolle

USDEA Schedule I; Home Office Schedule 1; stupéfiant (France); kontrollierte Droge in Deutschland; regulated under CDSA - not available from Sigma-Aldrich Canada

Methode(n)

HPLC: suitable
gas chromatography (GC): suitable

Anwendung(en)

clinical testing

Format

neat

SMILES String

Cl.CCOc1ccc(Cc2nc3cc(ccc3n2CCN(CC)CC)[N+]([O-])=O)cc1

InChI

1S/C22H28N4O3.ClH/c1-4-24(5-2)13-14-25-21-12-9-18(26(27)28)16-20(21)23-22(25)15-17-7-10-19(11-8-17)29-6-3;/h7-12,16H,4-6,13-15H2,1-3H3;1H

InChIKey

JTBRYBUIGVMMQL-UHFFFAOYSA-N

Anwendung

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem./physiol. Wirkung

A highly selective μ opioid receptor agonist. Reported to be 100-1000 times more potent than morphine in receptor binding studies and in behavioral studies.

Piktogramme

Skull and crossbones
GHS06

Signalwort

Danger

H-Sätze

H301,H336

Gefahreneinstufungen

Acute Tox. 3 Oral - STOT SE 3

Zielorgane

Central nervous system

Lagerklassenschlüssel

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flammpunkt (°F)

Not applicable

Flammpunkt (°C)

Not applicable

Persönliche Schutzausrüstung

Eyeshields, Gloves, type N95 (US)

Analysenzertifikate (COA)

Suchen Sie nach Analysenzertifikate (COA), indem Sie die Lot-/Chargennummer des Produkts eingeben. Lot- und Chargennummern sind auf dem Produktetikett hinter den Wörtern ‘Lot’ oder ‘Batch’ (Lot oder Charge) zu finden.

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T May et al.
Neuroscience letters, 275(2), 109-112 (1999-11-24)
Rats, for 8 weeks consuming the mu-opioid agonist etonitazene (forced and free choice conditions yielding high and low drug-consumers), were sacrificed after 2 days or 6 weeks lasting drug deprivation. Binding characteristics of membranes from the parieto-occipital cortex of these
Lionel Moulédous et al.
FEBS letters, 589(18), 2401-2408 (2015-08-01)
Many in vitro data have shown that the efficacy of several opioid drugs is correlated with differential mu-opioid (MOP) receptor phosphorylation. Label-free semiquantitative on-line nanoflow liquid chromatography-tandem mass spectrometry (nanoLC-MS/MS) analyses were performed to compare the endogenous MOP receptor phosphorylation
T P Piepponen et al.
Pharmacology, biochemistry, and behavior, 63(2), 245-252 (1999-06-17)
The role of mu1-opioid receptors in the acceleration of cerebral dopaminergic transmission induced by morphine and the putative mu1-opioid agonist, etonitazene, was studied in rats by measuring the tissue levels of dopamine (DA) and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and
G Zernig et al.
Life sciences, 57(23), 2113-2125 (1995-01-01)
In order to quantitate the extent to which opioid agonist potencies obtained in behavioral assays are determined by the apparent in vivo affinity and efficacy of the agonist, the antinociceptive effects of the mu opioid agonists morphine, fentanyl, etonitazene, and

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