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234A-1

Sigma-Aldrich

hCG Rabbit Polyclonal Antibody

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About This Item

UNSPSC-Code:
12352203
NACRES:
NA.41

Biologische Quelle

rabbit

Qualitätsniveau

100
500

Konjugat

unconjugated

Antikörperform

Ig fraction of antiserum

Antikörper-Produkttyp

primary antibodies

Klon

polyclonal

Beschreibung

For In Vitro Diagnostic Use in Select Regions (See Chart)

Form

buffered aqueous solution

Speziesreaktivität

human

Verpackung

vial of 0.1 mL concentrate (234A-14)
vial of 0.5 mL concentrate (234A-15)
bottle of 1.0 mL predilute (234A-17)
vial of 1.0 mL concentrate (234A-16)
bottle of 7.0 mL predilute (234A-18)

Hersteller/Markenname

Cell Marque

Methode(n)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:50-1:250

Kontrolle

placenta

Versandbedingung

wet ice

Lagertemp.

2-8°C

Visualisierung

cytoplasmic

Angaben zum Gen

human ... NUP42(11097)

Allgemeine Beschreibung

Human chorionic gonadotropin (hCG) is a hormone synthesized by syncytiotrophoblasts and belongs to a group of glycoprotein hormones known as gonadotropins. Gonadotropins regulate normal growth, sexual development, and reproductive function. This antibody detects syncytiotrophoblasts in placenta and in tumors such as choriocarcinoma and some cases of seminoma.
hCG is a protein secreted in large quantities by normal trophoblasts; the antibody detects cells and tumors of trophoblastic origin such as choriocarcinoma. Large cell carcinoma and adenocarcinoma of the lung demonstrate anti-hCG positivity in 90% and 60% of cases respectively. 20% of lung squamous cell carcinomas are positive for anti-hCG. hCG expression by non-trophoblastic tumors may indicate aggressive behavior since it has been observed that hCG may play a role in the host response to a given tumor.

Qualität


IVD

IVD

IVD

RUO

Verlinkung

hCG Positive Control Slides, Product No. 234S, are available for immunohistochemistry (formalin-fixed, paraffin-embedded sections).

Physikalische Form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Angaben zur Herstellung

Download the IFU specific to your product lot and formatNote: This requires a keycode which can be found on your packaging or product label.

Sonstige Hinweise

For Technical Service please contact: 800-665-7284 or email: service@cellmarque.com

Rechtliche Hinweise

Cell Marque is a trademark of Merck KGaA, Darmstadt, Germany

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Analysenzertifikate (COA)

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Die Dokumentenbibliothek aufrufen

Determination of biological activity of gonadotropins hCG and FSH by Forster resonance energy transfer based biosensors.?
Mazina, Olga et al.
Scientific Reports, 7, 42219-42219 (2017)
W L Davis et al.
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, 35(1), 39-48 (1987-01-01)
The calcium-regulating enzyme calcium adenosine triphosphatase (Ca-ATPase) was localized in the epithelium of amphibian urinary bladder by the one-step electron microscopic cytochemical procedure. The enzyme was identified along the basolateral border of the epithelial cells that comprise the bladder mucosa.
Choriogonadotropin positive seminoma-a clinicopathological and molecular genetic study of 15 cases.
Hes, Ondrej et al
Annals of diagnostic pathology, 18,2, 89-94 (2014)
R J Kurman et al.
Cancer, 38(6), 2404-2419 (1976-12-01)
The clinical and pathologic features of 71 endodermal sinus tumors of the ovary were studied in an effort to delineate the histogenesis and biologic behavior of this neoplasm and to evaluate the efficacy of different forms of treatment. Alpha-fetoprotein (AFP)
R J Kurman et al.
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists, 3(1), 101-121 (1984-01-01)
This report presents preliminary observations on the immunocytochemical localization of human chorionic gonadotropin (hCG) and human placental lactogen (hPL) in placental site trophoblastic tumors, hydatidiform moles, and choriocarcinomas and compares the findings with those of a similar immunocytochemical analysis of

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