5.08505

A-803467

• Synonym(e): A-803467, Sodium Channel Type 1.8 (Nav1.8) blocker, A-803467, A 803467, A803467
• Empirische Formel (Hill-System): C₁₉H₁₆ClNO₄
• CAS-Nummer: 944261-79-4
• Molekulargewicht: 357.79
• MDL-Nummer: MFCD10574689
• UNSPSC-Code: 12352200
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Qualitätsniveau: 100
• Form: solid
• Wirksamkeit: 8 nM IC₅₀
• Hersteller/Markenname: Calbiochem^®
• Lagerbedingungen: OK to freeze; protect from light
• Farbe: white
• Löslichkeit: DMSO: 100 mM; ethanol: 25 mM
• Lagertemp.: 2-8°C
• InChI: 1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
• InChIKey: VHKBTPQDHDSBSP-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A voltage gated sodium channel type 1.8 (Na_v1.8) pore blocker. Potently blocks tetrodotoxin-resistant currents (IC₅₀) = 140 nM) and the generation of spontaneous and electrically evoked action potentials in vitro in rat dorsal root ganglion neurons. In recombinant cell lines, A-803467 potently blocked human Na_v1.8 (IC₅₀ = 8 nM) and was >100-fold selective vs. human Na_v1.2, Na_v1.3, Na_v1.5, and Na_v1.7 (IC₅₀ values ≥ 1 µM).

Biochem./physiol. Wirkung

Primary Target
Na_v1.8

Warnhinweis

Toxicity: Standard Handling (A)

Sonstige Hinweise

Jarvis, M. F. et al. 2007. Proc. Natl. Acad. Sci. USA104, 8520.

Rechtliche Hinweise

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable