A3109

A-803467

≥98% (HPLC)

• Synonym(e): 5-4(-Chlorophenyl)-N-(3,5-dimethoxyphenyl)furan-2-carboxamide
• Empirische Formel (Hill-System): C₁₉H₁₆NO₄Cl
• CAS-Nummer: 944261-79-4
• Molekulargewicht: 357.79
• MDL-Nummer: MFCD10574689
• UNSPSC-Code: 12352200
• PubChem Substanz-ID: 329770815
• NACRES: NA.77

Eigenschaften

• Assay: ≥98% (HPLC)
• Form: powder
• Farbe: white to tan
• Löslichkeit: DMSO: >10 mg/mL
• Ersteller: Abbott
• Lagertemp.: room temp
• SMILES String: COc1cc(NC(=O)c2ccc(o2)-c3ccc(Cl)cc3)cc(OC)c1
• InChI: 1S/C19H16ClNO4/c1-23-15-9-14(10-16(11-15)24-2)21-19(22)18-8-7-17(25-18)12-3-5-13(20)6-4-12/h3-11H,1-2H3,(H,21,22)
• InChIKey: VHKBTPQDHDSBSP-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

A-803467 inhibits spontaneous and evoked action potentials in sensory neurons.[1] It exhibits antinociceptive effects.[2] A-803467 decreases the firing in spinal dorsal horn neurons in vivo.[3]

The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models.[4][5] A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic.[5]

Biochem./physiol. Wirkung

A-803467 blocks Nav1.8 in both half-maximal inactive and resting states with an IC₅₀ of 8 nM and IC₅₀ of 79 nM, respectively. A-803467 is over 100-fold more selective vs. human Nav1.2, 1.3, 1.5 and 1.7.[4]

Leistungsmerkmale und Vorteile

This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Sicherheitshinweise

• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable