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408719

Sigma-Aldrich

Polyethylenimin, verzweigt

average Mw ~800 by LS, average Mn ~600 by GPC

Synonym(e):

Ethylendiamin, verzweigt, PEI

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100 ML
€ 109,00
250 ML
€ 228,00
1 L
€ 543,00

€ 109,00

Voraussichtliches Versanddatum20. März 2025

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100 ML
€ 109,00
250 ML
€ 228,00
1 L
€ 543,00

About This Item

Lineare Formel:
H(NHCH2CH2)nNH2
CAS-Nummer:
25987-06-8
MDL-Nummer:
MFCD00084427
UNSPSC-Code:
12162002
NACRES:
NA.23

€ 109,00

Voraussichtliches Versanddatum20. März 2025

Bulk-Bestellung anfordern

Form

viscous liquid

Qualitätsniveau

200

Mol-Gew.

average Mn ~600 by GPC
average Mw ~800 by LS

Brechungsindex

n20/D 1.5240

Dichte

1.050 g/mL at 25 °C

SMILES String

N1CC1.NCCN

InChI

1S/C2H8N2.C2H5N/c3-1-2-4;1-2-3-1/h1-4H2;3H,1-2H2

InChIKey

SFLOAOINZSFFAE-UHFFFAOYSA-N

Verwandte Kategorien

Allgemeine Beschreibung

Polyethylenimin ist ein hydrophiles Polymer,das verbreitet als nichtviraler synthetischer Vektor für dieIn-vivo-Abgabe von therapeutischen Nukleinsäuren eingesetzt wird. Dank seiner ausgezeichnetenphysikochemischen Eigenschaften wird es in vielen Bereichen wie Trennungund Aufreinigung von Proteinen, Kohlenstoffdioxidabsorption, Arzneimittelträger,Abwasseraufbereitung und biologische Markierungen eingesetzt.

Anwendung

Verzweigtes PEI kann als Vorläufer für die Synthese von konjugierten Polyplexen für die effiziente Gentransfektion verwendet werden. Die Konjugation von PEI mit Jeffaminpolyether und die Guanidinylierung der Aminogruppen von PEI reduzieren die Zytotoxizität der Polyplexe und schützen sie vor der Aggregation in Gegenwart von Serumproteinen.

Mit PEI imprägnierte Bambuskohle kann als CO2-Adsorbens verwendet werden. Zahlreiche Aminogruppen in PEI können aufgrund ihrer Säure-Base-Wechselwirkung mit CO2 reagieren und die Adsorptionskapazität von Bambuskohle verbessern.

Es kann außerdem zum Herstellen von vernetzten wasserlöslichen Polymeren mit hoher Koordinationsfähigkeit mit organischen Arzneimittelmolekülen eingesetzt werden.

Leistungsmerkmale und Vorteile

  • Verzweigtes PEI weist bessere Komplexierungs- und Pufferkapazitäten auf.
  • Hohe Ionenaustauschkapazität und Affinität für Proteine.
  • SignifikanteDNA-Transfereffizienz.

Physikalische Form

Verzweigtes Polymer

Signalwort

Danger

Gefahreneinstufungen

Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1

Lagerklassenschlüssel

10 - Combustible liquids

WGK

WGK 3

Flammpunkt (°F)

356.0 °F

Flammpunkt (°C)

180 °C

Persönliche Schutzausrüstung

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
WXBF4895V
MKCV6718
MKCJ2767
MKCG7251
MKCG3800

Die passende Version wird nicht angezeigt?

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Die Dokumentenbibliothek aufrufen

Valentina Dinca et al.
Sensors (Basel, Switzerland), 18(12) (2018-12-07)
Developing a controlled method for obtaining hybrid enzymatic-based interfaces for sensing application require the use of a multiuse, reusable sensor. By controlling the interface characteristics in terms of the surface chemistry, thickness, and roughness, a tailored response toward various toxic
Andrew Jajack et al.
PloS one, 14(1), e0210286-e0210286 (2019-01-17)
Insurmountable detection challenges will impede the development of many of the next-generation of lab-on-a-chip devices (e.g., point-of-care and real-time health monitors). Here we present the first membrane-based, microfluidic sample preconcentration method that is continuous, quantifiable, simple, and capable of working
Irena Mamajanov et al.
Life (Basel, Switzerland), 10(8) (2020-08-23)
Enzymes are biological catalysts that are comprised of small-molecule, metal, or cluster catalysts augmented by biopolymeric scaffolds. It is conceivable that early in chemical evolution, ancestral enzymes opted for simpler, easier to assemble scaffolds. Herein, we describe such possible protoenzymes:
Anna Alhaddad et al.
PloS one, 7(12), e52207-e52207 (2013-01-04)
Small interfering RNAs (siRNAs) are powerful tools commonly used for the specific inhibition of gene expression. However, vectorization is required to facilitate cell penetration and to prevent siRNA degradation by nucleases. We have shown that diamond nanocrystals coated with cationic
Jonathon M Muncie et al.
Developmental cell, 55(6), 679-694 (2020-11-19)
Embryogenesis is directed by morphogens that induce differentiation within a defined tissue geometry. Tissue organization is mediated by cell-cell and cell-extracellular matrix (ECM) adhesions and is modulated by cell tension and tissue-level forces. Whether cell tension regulates development by modifying
Alle zugehörigen Dokumente anzeigen

Artikel

Functionalized PEI and Its Role in Gene Therapy

Gene therapy has become one of the most discussed techniques in biomedical research in recent years.

Nanoparticle-Based Drug and Gene Delivery for Tumor Targeting

Professor Yoshiki Katayama (Kyushu University, Japan) discusses recent advances in drug delivery systems and strategies that exploit the EPR effect, with a special focus on stimuli-responsive systems based on novel materials.

Progress on Nonviral Delivery for CRISPR/Cas9

CRISPR/Cas9 delivery via nonviral nanoparticles shows promising advancements for gene editing in disease treatment.

Polyelectrolyte Multilayer Films and Membrane Functionalization

We present an article that discusses two applications in particular; first, using these layers as polyelectrolyte membranes to control permeability.

Alle anzeigen

Questions

1–7 of 7 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. 1) What is the maximum wt % absorption of CO2 relative to the weight of PEI 2) Does PEI liquid absorb CO2 by surface absorption/adhesion - or by diffusion into the fluid?

    1 answer

    1. Theoretically, it’s about equal amounts of CO2 and PEI by mass. The effective monomeric unit of the PEI is the (-CH2CH2NH-) group, with a formula weight of 43.07. The formula weight of carbon dioxide is 44.01. Each monomeric unit of the PEI can react with one molecule of CO2, and since 43.07 is so close to 44.01, the weight of the PEI and the CO2 would be almost the same. Practically speaking, the reaction is probably not 100% efficient.
      The PEI absorbs the CO2 by a chemical reaction…an acid-base reaction. Carbon dioxide in aqueous solution is sometimes referred to as carbonic acid. (CO2 + H2O ---> H2CO3) And the amino groups of the PEI are the base. The reaction product is a protonated amine (-NH3 + or -NHR2 +) with a bicarbonate anion (HCO3 - ) as the counterion.

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  4. Is this product soluble in water ?

    1 answer

    1. This material is readily soluble in water, ethanol, methanol, isopropanol, and n-propanol. In addition, the product is partially soluble in ethyl acetate, toluene, and xylene. Other sources report that this PEI is also soluble in chloroform.

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  5. What is the percentage of Polyethylenimine in the solution?

    1 answer

    1. This product is considered a neat/pure material. It just happens to be a liquid at room temperature, but it is not in solution; there is no solvent added.

      Helpful?

  6. What is the n value in the structure of this PEI?

    1 answer

    1. The n value in the structure is not determined.

      Helpful?

  7. What's the molar ratio of primary, secondary and tertiary amines?

    1 answer

    1. The molar ratio of the primary, secondary, and tertiary amines is not determined. However, the amine value is approximately 576 (primary and secondary). This product is PEI800 and equivalent to Lupasol FG.
      See the link below for a paper that suggests a general amine ratio (Table 6):
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5872989/

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