159034

Acetohydroxamsäure

98%

• Synonym(e): AHA
• Lineare Formel: CH₃CONHOH
• CAS-Nummer: 546-88-3
• Molekulargewicht: 75.07
• Beilstein: 1739019
• EG-Nummer: 208-913-8
• MDL-Nummer: MFCD00009994
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24849786
• NACRES: NA.22

Eigenschaften

• Qualitätsniveau: 100
• Assay: 98%
• mp (Schmelzpunkt): 88-90 °C (lit.)
• Funktionelle Gruppe: amine
• SMILES String: CC(NO)=O
• InChI: 1S/C2H5NO2/c1-2(4)3-5/h5H,1H3,(H,3,4)
• InChIKey: RRUDCFGSUDOHDG-UHFFFAOYSA-N
• Angaben zum Gen: human ... CA2(760) , MMP3(4314)

Beschreibung

Allgemeine Beschreibung

Acetohydroxamic acid is a potent inhibitor of bacterial urease activity and reduces urinary ammonia levels.[1] 2-Acetohydroxamic acid loaded floating microspheres forms an efficient drug delivery system for the treatment of Helicobacter pylori.[2]

Anwendung

Used in urease inhibition studies[3][4] and for in situ generation of nitrosocarbonylmethane as a Diels-Alder dienophile.[5]

Acetohydroxamic acid was used:

• to study the mechanism of complexation of iron (III) with acetohydroxamic acid[6]
• to study the inhibitory mechanism of lansoprazole and omeprazole on Helicobacter pyloni[7]
• in urease inhibition studies[3][4]
• for in situ generation of nitrosocarbonylmethane as a Diels-Alder dienophile[5]

Sicherheitshinweise

• Piktogramme: GHS08
• Signalwort: Danger
• H-Sätze: H360
• P-Sätze: P201 - P308 + P313
• Gefahreneinstufungen: Repr. 1B
• Lagerklassenschlüssel: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Persönliche Schutzausrüstung: Eyeshields, Gloves, type P2 (EN 143) respirator cartridges