134155

1-Methylindol-2-carbonsäure

98%

• Synonym(e): NSC 68357
• Empirische Formel (Hill-System): C₁₀H₉NO₂
• CAS-Nummer: 16136-58-6
• Molekulargewicht: 175.18
• MDL-Nummer: MFCD00005801
• UNSPSC-Code: 12352100
• PubChem Substanz-ID: 24848134
• NACRES: NA.22

Eigenschaften

• Assay: 98%
• Form: powder
• mp (Schmelzpunkt): 212-213 °C (dec.) (lit.)
• SMILES String: Cn1c(cc2ccccc12)C(O)=O
• InChI: 1S/C10H9NO2/c1-11-8-5-3-2-4-7(8)6-9(11)10(12)13/h2-6H,1H3,(H,12,13)
• InChIKey: MAHAMBLNIDMREX-UHFFFAOYSA-N

Beschreibung

Allgemeine Beschreibung

1-Methylindole-2-carboxylic acid reacts with thionyl chloride to yield sulfinyl chlorides.

Anwendung

• Reactant for preparation of keto-indoles as novel indoleamine 2,3-dioxygenase (IDO) inhibitors
• Reactant for synthesis of fenbufen and ethacrynic acid derivatives as potential antitumor agents via amide coupling reactions
• Reactant for diastereoselective synthesis of vinylated heterocycles via ruthenium-catalyzed oxidative vinylation with alkenes
• Reactant for synthesis of 2,3-dihalo indoles via hypervalent iodine mediated decarboxylative halogenation
• Reactant for preparation of α-ketoamides as cathepsin S inhibitors with potential applications against tumor invasion and angiogenesis
• Reactant for preparation of anthranilic acid mimics as bacterial translation inhibitors

Sicherheitshinweise

• Piktogramme: GHS07
• Signalwort: Warning
• H-Sätze: H302,H315,H319,H335
• P-Sätze: P261 - P264 - P270 - P301 + P312 - P302 + P352 - P305 + P351 + P338
• Gefahreneinstufungen: Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Zielorgane: Respiratory system
• Lagerklassenschlüssel: 11 - Combustible Solids
• WGK: WGK 3
• Flammpunkt (°F): Not applicable
• Flammpunkt (°C): Not applicable
• Persönliche Schutzausrüstung: dust mask type N95 (US), Eyeshields, Faceshields, Gloves