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105228

Sigma-Aldrich

1,1,1,3,3,3-Hexafluor-2-propanol

1,1,1,3,3,3-Hexafluoro-2-propanol

≥99%

Synonym(e):

HFP, Hexafluorisopropanol

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About This Item

Lineare Formel:
(CF3)2CHOH
CAS-Nummer:
920-66-1
Molekulargewicht:
168.04
Beilstein:
1841007
EG-Nummer:
213-059-4
MDL-Nummer:
MFCD00011651
UNSPSC-Code:
12352104
PubChem Substanz-ID:
24846695
NACRES:
NA.22
Assay:
≥99%
Preise und Verfügbarkeit sind derzeit nicht verfügbar.

Qualitätsniveau

200

Assay

≥99%

Brechungsindex

n20/D 1.275 (lit.)

bp

59 °C (lit.)

mp (Schmelzpunkt)

−4 °C (lit.)

Dichte

1.596 g/mL at 25 °C (lit.)

Funktionelle Gruppe

fluoro
hydroxyl

SMILES String

OC(C(F)(F)F)C(F)(F)F

InChI

1S/C3H2F6O/c4-2(5,6)1(10)3(7,8)9/h1,10H

InChIKey

BYEAHWXPCBROCE-UHFFFAOYSA-N

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Allgemeine Beschreibung

1,1,1,3,3,3-Hexafluor-2-propanol ist ein Lösungsmittel für die Peptidchemie in der Lösungsphase.[1] Dieses fluorierte polare Lösungsmittel mit hoher Ionisierungskraft erleichtert Reaktionen vom Friedel-Crafts-Typ unter Verwendung kovalenter Reagenzien in Abwesenheit eines Lewis-Säure-Katalysators.[2] Es verbessert außerdem die Wirksamkeit von Rhodium(I)-katalysierten intramolekularen [4+2]-Cycloadditionen von ethergebundenen Alkinyldienen und [5+2]-Cycloadditionen von Alkinylvinylcyclopropanen.[3] 1,1,1,3,3,3-Hexafluor-2-propanol-Cluster katalysieren die Epoxidation von Cycloocten und 1-Octen mit Wasserstoffperoxid.[4]

Anwendung

1,1,1,3,3,3-Hexafluor-2-propanol wurde zur Herstellung von Hexafluoroalkohol-funktionalisierten Methacrylat-Polymeren für lithographische Materialien bzw. Materialien mit Nanostrukturierung[5] verwendet.

Piktogramme

Health hazardCorrosion
GHS08,GHS05

Signalwort

Danger

Gefahreneinstufungen

Eye Dam. 1 - Repr. 2 - Skin Corr. 1A - STOT RE 2 Oral

Zielorgane

Central nervous system

Lagerklassenschlüssel

8B - Non-combustible corrosive hazardous materials

WGK

WGK 2

Flammpunkt (°F)

No data available

Flammpunkt (°C)

No data available

Persönliche Schutzausrüstung

Faceshields, Gloves, Goggles

Hier finden Sie alle aktuellen Versionen:

Analysenzertifikate (COA)

Lot/Batch Number
MKCX1650
WXBF3887V
WXBF2560V
WXBF3127V
MKCW5219

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Die Dokumentenbibliothek aufrufen

Rita Sobreiro-Almeida et al.
Materials science & engineering. C, Materials for biological applications, 103, 109866-109866 (2019-07-28)
Kidney diseases are recognized as a major health problem, which affect 10% of the population. Because currently available therapies have many limitations, some tissue engineering strategies have been emerging as promising approaches in this field. In this work, porcine kidneys
Hexafluoroalcohol-functionalized Methacrylate Monomers for Lithographic/Nanopatterning Materials.
Sanders DP, et al.
Material Matters, 6(1), 1-7 (2011)
Kinetic Studies of Olefin Epoxidation with Hydrogen Peroxide in 1, 1, 1, 3, 3, 3-Hexafluoro-2-propanol Reveal a Crucial Catalytic Role for Solvent Clusters.
Berkessel A and Adrio JA.
Advanced Synthesis & Catalysis, 346(2-3), 275-280 (2004)
Akio Saito et al.
The Journal of organic chemistry, 71(17), 6437-6443 (2006-08-12)
In fluorinated alcohols, the cationic Rh(I) species, which is derived from [Rh(COD)Cl]2 and AgSbF6, efficiently catalyzed intramolecular [4+2] cycloaddition reactions of ester-tethered 1,3-diene-8-yne derivatives. The catalytic system was also effective in intramolecular [5+2] cycloaddition reactions of ester-tethered omega-alkynyl vinylcyclopropane compounds.
Lewis acid catalyst free electrophilic alkylation of silicon-capped pi donors in 1,1,1,3,3,3-hexafluoro-2-propanol.
Maxim O Ratnikov et al.
Angewandte Chemie (International ed. in English), 47(50), 9739-9742 (2008-11-05)
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Artikel

Hexafluoroalcohol-functionalized Methacrylate Monomers for Lithographic/nanopatterning materials

To keep pace with Moore′s Law, there is a continuing need in the semiconductor industry to achieve higher circuit density in microelectronic devices.

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Questions

1–10 of 13 Questions  

  1. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  2. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  3. Does this material have traces of trifluoroacetone, and if so what % or ppm?

    1 answer

    1. This product is not tested for the presence of Trifluoroacetone.

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  4. It is supplied in a pressurized metal can in powder form, and once we store it in the refrigerator, it becomes a liquid. However, it doesn't seem to have a resealable container based on its appearance. Do you have any storage suggestions after opening it?

    1 answer

    1. This product is a liquid, with a melting point of ?4 °C and a density of 1.596 g/mL. The liquid is packaged in an amber glass bottle with a polypropylene screw cap. In order to preserve the quality of the product, as well as protect it from damage, the bottle is placed in a metal overpack can. This can is not under pressure. Dry material within the can is NOT the product, but is simply absorbent packing material should breakage occur.

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  5. Why is the pack size in grams when it is a liquid?

    1 answer

    1. This item is a neat or pure liquid that is sold by weight rather than volume. The melting/freezing point is approximately -4°C. The density of this material is 1.596 g/mL at 25 °C.

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  6. Is this product packaged under inert gas?

    1 answer

    1. This product is not stored under inert gas. The label recommends storing in the refrigerator prior to opening. This is to alleviate some of the built up pressure. Long term storage is at room temperature.

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  7. Is this material deuterated or normal? Please confirm

    1 answer

    1. This product is not deuterated. A deuterated version of this chemical is product number 411302: https://www.sigmaaldrich.com/US/en/product/aldrich/411302

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  8. Can Product 105228, 1,1,1,3,3,3-Hexafluoro-2-propanol, be used as a solution phase peptide chemistry solvent?

    1 answer

    1. This product is a solution phase peptide chemistry solvent an that applications has been cited in literature.  A specific reference would be:  Biochem. 29, 2639 (1990).

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  9. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  10. What is Product 105228, 1,1,1,3,3,3-Hexafluoro-2-propanol, soluble in?

    1 answer

    1. According to literature, 1,1,1,3,3,3-Hexafluoro-2-propanol is soluble in 100% ethanol (to 10% v/v), which will yield colorless solution, chloroform, and water.

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1–10 of 13 Questions  

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