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T8566

L-Tyrosine

99.0-101.0%, suitable for cell culture, BioXtra, non-animal source

Synonym(s):

(S)-2-Amino-3-(4-hydroxyphenyl)propionic acid, 3-(4-Hydroxyphenyl)-L-alanine

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Pack SizeSKUAvailabilityPrice
10 mg
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$43.70
25 g
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$70.70
100 g
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$235.00
1 kg
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$1,280.00

About This Item

Linear Formula:
4-(HO)C6H4CH2CH(NH2)CO2H
CAS Number:
Molecular Weight:
181.19
NACRES:
NA.26
PubChem Substance ID:
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
200-460-4
MDL number:
Beilstein/REAXYS Number:
392441

$43.70


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Product Name

L-Tyrosine, from non-animal source, meets EP, USP testing specifications, suitable for cell culture, 99.0-101.0%

biological source

non-animal source

Quality Level

agency

USP/NF, meets EP testing specifications, meets USP testing specifications

product line

BioXtra

assay

99.0-101.0%

form

powder

optical activity

[α]25/D 11.2 to 9.8°, c = 5 in 1 M HCl (Specific Rotation 6.1 - 7.8 °)

shelf life

limited shelf life, expiry date on the label

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white to off-white

mp

>300 °C (dec.) (lit.)

solubility

1 M HCl: 25 mg/mL

cation traces

Fe: ≤10 ppm, NH4+: ≤0.02%

application(s)

advanced drug delivery
pharmaceutical (small molecule)

functional group

(phenol)

storage temp.

room temp

SMILES string

N[C@@H](Cc1ccc(O)cc1)C(O)=O

InChI

1S/C9H11NO3/c10-8(9(12)13)5-6-1-3-7(11)4-2-6/h1-4,8,11H,5,10H2,(H,12,13)/t8-/m0/s1

InChI key

OUYCCCASQSFEME-QMMMGPOBSA-N

General description

L-Tyrosine, an essential amino acid, plays a vital role in biochemical and cell culture research. In biochemical studies, L-Tyrosine is significant as a precursor to neurotransmitters like dopamine, norepinephrine, and epinephrine, which influence cellular communication and play a role in mood, attention, and energy levels. It also contributes to the synthesis of thyroid hormones, regulating metabolic processes. L-Tyrosine is employed to support cell growth and protein synthesis, facilitating experiments on cell maintenance and repair, making it a valuable tool in biochemical and cell culture investigations.

Application

L-Tyrosine has been used as a supplement in Dulbecco′s modified Eagle′s medium for culturing SY5Y neuroblastoma cells for stable isotope labeling of amino acids on cell culture (SILAC).

Biochem/physiol Actions

L-Tyrosine consists of a polar side chain and is a non-essential amino acid. It is utilized by cells to synthesize proteins that are involved in signal transduction. L-Tyrosine acts as a receiver of phosphate groups that are transferred by kinases.

Features and Benefits

  • Suitable for Cell Culture and Biochemical research
  • High-quality compound suitable for multiple research applications

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Other Notes

Amino acid precursor of dopamine and other catecholamines
For additional information on our range of Biochemicals, please complete this form.

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1 of 1

This Item
PHR1097T4321T2900000
form

powder

form

-

form

crystalline powder

form

-

functional group

(phenol)

functional group

-

functional group

-

functional group

-

technique(s)

cell culture | mammalian: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

cell culture | mammalian: suitable

technique(s)

-

assay

99.0-101.0%

assay

-

assay

≥99%

assay

-

product line

BioXtra

product line

-

product line

-

product line

-

storage temp.

room temp

storage temp.

2-30°C

storage temp.

-

storage temp.

2-8°C


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ppe

dust mask type N95 (US), Eyeshields, Gloves

flash_point_f

Not applicable

flash_point_c

Not applicable

Storage Class

11 - Combustible Solids



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Articles

Learn more about the amino acid L-Tyrosine and explore how it is used in cell culture media like MEM, DMEM, and RPMI. We offer a comprehensive portfolio of amino acid cell culture supplements and reagents.


Chemistry, An Introduction to General, Organic, and Biological Chemistry (2016)
Altering O-Linked ?-N-Acetylglucosamine Cycling Disrupts Mitochondrial Function
Ee Phie Tan
The Journal of Biological Chemistry, 14719-14730 (2014)
John W Hill
Chemistry for Changing Times (2016)



Global Trade Item Number

SKUGTIN
T8566-1KG04061837379369
T8566-100G04061837379345
T8566-10MG04061837379352
T8566-25G04061835514311

Questions

1–4 of 4 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. How to make 50mM stock solution with pH around 7 for cell culture? Is it even possible? There were large amount of precipitation everytime when I tried to adjust the pH...

    1 answer
    1. L-tyrosine has a very low solubility (0.45 mg/ml) in water at neural pH. To prepare a stock solution, L-tyrosine is dissolved at an extreme pH, either below pH 2 or above pH 9. It can also be dissolved in organic solvent such as DMSO with higher solubility.

      L-tyrosine disodium salt dihydrate has a much better solubility (100 mg/ml) when compared to L-tyrosine. To avoid introducing pH shock, un-wanted solvent, or high salt into the medium, dipeptides that contain L-tyrosine, such as glycyl-L-tyrosine, are a reliable replacement when high concentrations of L-tyrosine are required.

      Helpful?

  3. How can I solubilise this product

    1 answer
    1. As listed in the 'PROPERTIES' section, this product is soluble in 1 M HCL at 25 mg/mL.

      Helpful?

  4. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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