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Anti-LAMP-1 antibody produced in rabbit

Name: Anti-LAMP-1 antibody produced in rabbit
Brand: SIGMA
Price: 584 USD

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Lysosome associated membrane protein 1

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Pack Size	SKU	Availability	Price
100 μg		Check Cart for Availability	$584.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01864611

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IF, IHC, WB

Citations:

$584.00

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Properties

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 46 kDa

species reactivity

rat, human, mouse

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

NCBI accession no.

NP_005552

UniProt accession no.

P11279

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... LAMP1(3916)

Description

General description

Lysosomal-associated membrane protein 1 (LAMP-1) is a type I transmembrane protein with a short cytoplasmic tail containing a lysosome-targeting signal. The gene encoding this protein is localized on human chromosome 13q34.

Immunogen

LAMP-1 antibody was raised against a 15 amino acid peptide from near the center of human LAMP-1.

Application

Anti-LAMP-1 antibody produced in rabbit has been used in Western blotting.

Biochem/physiol Actions

Lysosomal-associated membrane protein 1 (LAMP-1) functions as an intracellular receptor. It is found to be expressed in the cytoplasm of several types of tumor cells and may be involved in tumor invasion. LAMP-1 is essential for perforin trafficking to the lytic granules and motility of these lytic granules. Knockdown of this protein leads to inhibition of cytotoxicity of human natural killer cells.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied in PBS with 0.02% sodium azide.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500285.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

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This Item	L0419	HPA014750	AB2971
Sigma-Aldrich SAB3500285 Anti-LAMP-1 antibody produced in rabbit	Sigma-Aldrich L0419 Anti-LAMP1−Cy3^™ antibody produced in rabbit	Sigma-Aldrich HPA014750 Anti-LAMP1 antibody produced in rabbit	Sigma-Aldrich AB2971 Anti-LAMP-1 (CD107a) Antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate CY3 conjugate	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
shipped in dry ice	shipped in wet ice	shipped in wet ice	shipped in ambient
technique(s) immunofluorescence: suitable, indirect ELISA: suitable, immunohistochemistry: suitable, western blot: suitable	technique(s) direct immunofluorescence: 1-2 μg/mL using human HeLa cells, rat NRK cells and mouse 3T3 cells	technique(s) immunohistochemistry: 1:200- 1:500	technique(s) immunocytochemistry: suitable, western blot: suitable

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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LAMP1/CD107a is required for efficient perforin delivery to lytic granules and NK-cell cytotoxicity.

Krzewski K

Blood (2013)

A dynamic network of estrogen receptors
in murine lymphocytes: fine-tuning
the immune response

Andrea E. Schneider

Journal of Leukocyte Biology (2017)

Expression of the lysosomal-associated membrane protein-1 (LAMP-1) in astrocytomas.

Jensen SS

International Journal of Clinical and Experimental Pathology (2013)

View All Related Papers

Global Trade Item Number

SKU	GTIN
SBP3500285-0.05MG	04061832168821
SAB3500285-100UG	04061832179414

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