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SAB3500002

Anti-TTBK1 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-BDTK, Anti-Brain derived tau kinase, Anti-Tau tubulin kinase 1

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100 μG

$529.00

$529.00

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About This Item

NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
ELISA (i), IF, IHC, WB
Citations:
4

Key Documents

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biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 145-151 kDa

species reactivity

human, mouse

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

NCBI accession no.

Q5TCY1

UniProt accession no.

Q5TCY1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... TTBK1(84630)

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This Item
HPA060211SAB1410579SAB2104892
Anti-TTBK1 antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

SAB3500002

Anti-TTBK1 antibody produced in rabbit

Anti-TBK1 antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody

Sigma-Aldrich

HPA060211

Anti-TBK1 antibody produced in rabbit

Anti-TBK1 antibody produced in rabbit purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

SAB1410579

Anti-TBK1 antibody produced in rabbit

Anti-TBK1 antibody produced in rabbit affinity isolated antibody

Sigma-Aldrich

SAB2104892

Anti-TBK1 antibody produced in rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

species reactivity

human, mouse

species reactivity

human

species reactivity

human

species reactivity

dog, rabbit, rat, guinea pig, bovine, horse, human, mouse

mol wt

predicted mol wt 145-151 kDa

mol wt

-

mol wt

antigen 83.6 kDa

mol wt

84 kDa

General description

Tau tubulin kinase (TTBK1) belongs to the casein kinase 1 superfamily and is involved in the phosphorylation of specific serine/threonine residues in paired helical filaments of the tau protein. It is specifically expressed in the brain and induces tau aggregation in human neuronal cells in a dose-dependent manner. TTBK1 levels have been found to be upregulated in the brains of Alzheimer′s disease (AD) patients, and mice expressing human TTBK1 protein showed significant age-dependent memory impairment. These mice displayed increased levels of the CDK5 activators p25 and p35, and reduced levels of the NMDA receptor types 2B and 2D, suggesting that TTBK1 may play a role in memory dysfunction in AD patients. Multiple isoforms of TTBK1 are known to exist. This antibody is predicted to not cross-react with TTBK2.
Tau tubulin kinase 1 (TTBK1) is a serine/threonine and tyrosine kinase. It belongs to the casein kinase 1 superfamily and is neuron-specific. The encoded protein has a kinase domain, a unique polyglutamate domain and several PEST (proline–glutamate–serine–threonine) sequences. The gene encoding TTBK1 is localized on human chromosome 6p21.1.

Immunogen

TTBK1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human TTBK1.

Application

Anti-TTBK1 antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Tau tubulin kinase 1 (TTBK1) is responsible for phosphorylation of TDP-43 (TAR DNA binding protein), a protein associated with amyotrophic lateral sclerosis and frontotemporal lobar dementia. High expression or abundance of TTBK1 might be associated with neurodegeneration in these diseases. It also phosphorylates tau protein and might be associated with Alzheimer′s disease progression.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

Supplied at approx. 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3500002.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Product No.
Description
Pricing

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
50130901

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The structure of human tau-tubulin kinase 1 both in the apo form and in complex with an inhibitor.
Kiefer SE
Acta Crystallographica. Section F, Structural Biology Communications (2014)
The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43.
Liachko NF
PLoS Genetics (2014)
The Tau Tubulin Kinases TTBK1/2 Promote Accumulation of Pathological TDP-43
Nicole F
PLoS Genetics (2014)
Nicole F Liachko et al.
PLoS genetics, 10(12), e1004803-e1004803 (2014-12-05)
Pathological aggregates of phosphorylated TDP-43 characterize amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD-TDP), two devastating groups of neurodegenerative disease. Kinase hyperactivity may be a consistent feature of ALS and FTLD-TDP, as phosphorylated TDP-43 is not observed in the

Global Trade Item Number

SKUGTIN
SBP3500002-0.05MG04061832166148
SAB3500002-100UG04061832493916

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