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Anti-IRF7 (ab1) antibody produced in rabbit

Name: Anti-IRF7 (ab1) antibody produced in rabbit
Brand: SIGMA
Price: 614 USD

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Interferon regulatory factor 7

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Pack Size	SKU	Availability	Price
100 μg		Check Cart for Availability	$614.00

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02096777

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IF, IHC, WB

Citations:

$614.00

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Properties

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

human, rat, mouse

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

UniProt accession no.

Q92985

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... IRF7(3665)

Description

General description

Interferon regulatory factor 7 (IRF7) protein, a multifunctional transcription factor, is a lymphoid-specific factor expressed in the cytoplasm in B cells, plasmacytoid dendritic cells (pDCs), and monocytes in the spleen, thymus, and peripheral blood lymphocytes. IRF7 gene is located on human chromosome 11p15.5.

Immunogen

a peptide corresponding to 14 amino acids near the carboxy-terminus of human IRF7 .

Application

Anti-IRF7 (ab1) antibody produced in rabbit has been used in immunoblotting.[1]

Biochem/physiol Actions

Interferon regulatory factor 7 (IRF7) protein plays a key role in regulating the type I interferon (IFN) alpha/beta (IFNα/β) responses, which are necessary to innate and adaptive immunity. Hence IRF7 is considered as the ‘master′ controller of IFN type I production. It plays a key role in priming. IRF7 can also form homodimers or heterodimers with interferon regulatory factor 5 (IRF5) to modulate target genes. It might regulate oncogenesis and apoptosis. IRF7 plays an important role in the pathogenesis of type I diabetes. It is connected to the latency of the Epstein–Barr virus (EBV).

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Other Notes

The action of this antibody can be blocked using blocking peptide SBP3941.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	ABF202	HPA052757	AV38128
Sigma-Aldrich PRS3941 Anti-IRF7 (ab1) antibody produced in rabbit	Sigma-Aldrich ABF202 Anti-IRF7 Antibody	Sigma-Aldrich HPA052757 Anti-IRF7 antibody produced in rabbit	Sigma-Aldrich AV38128 Anti-IRF1 (AB2) antibody produced in rabbit
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level -
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
species reactivity human, rat, mouse	species reactivity human, mouse	species reactivity human	species reactivity sheep, rabbit, guinea pig, rat, dog, human, mouse, bovine, horse
technique(s) immunofluorescence: suitable, indirect ELISA: suitable, immunohistochemistry: suitable, western blot: suitable	technique(s) immunofluorescence: suitable, immunohistochemistry: suitable, western blot: suitable	technique(s) immunofluorescence: 0.25-2 μg/mL, immunohistochemistry: 1:50-1:200	technique(s) immunohistochemistry: suitable, western blot: suitable

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

39412001

39410603

3941-0603

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IRF7: activation, regulation, modification and function.

S Ning et al.

Genes and immunity, 12(6), 399-414 (2011-04-15)

Interferon regulatory factor 7 (IRF7) was originally identified in the context of Epstein-Barr virus (EBV) infection, and has since emerged as the crucial regulator of type I interferons (IFNs) against pathogenic infections, which activate IRF7 by triggering signaling cascades from

Andrographolide inhibits chikungunya virus infection by up-regulating host innate immune pathways

Gupta S, et al.

Asian Pacific Journal of Tropical Medicine (2018)

Pioglitazone Ameliorates Gentamicin Ototoxicity by Affecting the TLR and STAT Pathways in the Early Postnatal Organ of Corti.

Marijana Sekulic-Jablanovic et al.

Frontiers in cellular neuroscience, 14, 566148-566148 (2020-11-17)

Noise trauma, infection, and ototoxic drugs are frequent external causes of hearing loss. With no pharmacological treatments currently available, understanding the mechanisms and pathways leading to auditory hair cell (HC) damage and repair is crucial for identifying potential pharmacological targets.

Global Trade Item Number

SKU	GTIN
SBP3941-0.05MG	04061832162744
PRS3941-100UG	04061832178943

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