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Anti-MTBP antibody produced in rabbit

Name: Anti-MTBP antibody produced in rabbit
Brand: SIGMA
Price: 723 CAD

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-Mdm2, transformed 3T3 cell double minute 2, p53 binding protein (mouse) binding protein, 104kDa

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Pack Size	SKU	Availability	Price
100 μg		Please contact Customer Service for Availability	$723.00

About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), ICC, IF, WB

Citations:

$723.00

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Properties

biological source

rabbit

Quality Level

100

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 104 kDa

species reactivity

human

technique(s)

immunocytochemistry: suitable, immunofluorescence: suitable, indirect ELISA: suitable, western blot: suitable

UniProt accession no.

Q96DY7

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MTBP(27085)

Description

Immunogen

a synthetic peptide corresponding to amino acids 122-139 of human MTBP, which differ from mouse by three amino acids.

Biochem/physiol Actions

The gene MTBP (Mdm2-binding protein) is mapped to human chromosome 8q24. It is involved in the development and progression of cancer. In hepatocellular carcinoma, MTBP enhances MDM2 (E3 ubiquitin-protein ligase)-associated degradation of E-cadherin. It is also suggested as a therapeutic target for treatment of triple-negative breast cancer. MTBP is a transcriptional target of Myc. It plays an important role in cell cycle progression. Silencing of this gene causes delay in cell cycle progress at S and G2/M phases.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Other Notes

The action of this antibody can be blocked using blocking peptide SBP2447.

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Show Differences

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This Item	HPA025694	HPA049222	HPA054862
Sigma-Aldrich PRS2447 Anti-MTBP antibody produced in rabbit	Sigma-Aldrich HPA025694 Anti-MTBP antibody produced in rabbit	Sigma-Aldrich HPA049222 Anti-MBP antibody produced in rabbit	Sigma-Aldrich HPA054862 Anti-MTTP antibody produced in rabbit
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level -
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
UniProt accession no. Q96DY7	UniProt accession no. Q96DY7	UniProt accession no. P02686	UniProt accession no. P55157
shipped in dry ice	shipped in wet ice	shipped in wet ice	shipped in wet ice

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

24470201

2447-0201

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Assignment of the MDM2 binding protein gene (MTBP) to human chromosome band 8q24 by in situ hybridization.

Boyd MT

Cytogenetics and Cell Genetics, 90, 64-65 (2000)

MTBP is overexpressed in triple-negative breast cancer and contributes to its growth and survival.

Grieb BC

Molecular Cancer Research, 12, 1216-1224 (2014)

MTBP Promotes the Invasion and Metastasis of Hepatocellular Carcinoma by Enhancing the MDM2-Mediated Degradation of E-Cadherin.

Lu S

Digestive Diseases and Sciences, 60, 3681-3690 (2015)

Global Trade Item Number

SKU	GTIN
SBP2447-0.05MG	04061832165851
PRS2447-100UG	04061831489309

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