Key Documents

View All Documentation

Anti-CX3CL1 antibody produced in rabbit

Name: Anti-CX3CL1 antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-CX3C, Anti-Chemokine (C-X3-C motif) ligand 1

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01864668

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IP, WB

Citations:

This product is discontinued. Contact Technical Servicefor assistance.

Properties

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

species reactivity

mouse, human

technique(s)

immunoprecipitation (IP): suitable, indirect ELISA: suitable, western blot: suitable

UniProt accession no.

P78423

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CX3CL1(6376)

Description

General description

Chemokine (C-X3-C motif) ligand 1 (CX3CL1) or fractalkine is a membrane protein and part of the CXC3 family. Its chemokine domain (CKD) anchors it to the cell membrane through its mucin-like stalk. The protein acts as a ligand for the G-protein coupled receptor CX3CR1. Fractalkine is expressed on epithelial, endothelial and smooth muscle cells and in neurons. The gene encoding it is localized on human chromosome 16q21.

Immunogen

a peptide corresponding to 18 amino acids near the amino-terminus of human CX3CL1.

Biochem/physiol Actions

CX3CL1 (chemokine (C-X3-C motif) ligand 1) or fractalkine is involved in various disorders such as atherosclerosis, multiple sclerosis, neuropathic pain and rheumatic disorders. It facilitates the proliferation and survival of primary human vascular smooth muscle cells in an epidermal growth factor receptor (EGR)–dependent manner. The protein plays an essential role in cell survival and promotes the survival of cells such as monocytes, T-cells and microglia. In humans, it may be involved in atherogenesis.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Other Notes

The action of this antibody can be blocked using blocking peptide SBP2099.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	SAB3501185	WH0006376M1	HPA046587
Sigma-Aldrich PRS2099 Anti-CX3CL1 antibody produced in rabbit	Sigma-Aldrich SAB3501185 Anti-CX3CL1 antibody produced in rabbit	Sigma-Aldrich WH0006376M1 Monoclonal Anti-CX3CL1 antibody produced in mouse	Sigma-Aldrich HPA046587 Anti-CX3CR1 antibody produced in rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form affinity isolated antibody
biological source rabbit	biological source rabbit	biological source mouse	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Gene Information human ... CX3CL1(6376)	Gene Information human ... CX3CL1(6376)	Gene Information human ... CX3CL1(6376)	Gene Information human ... CX3CR1(1524)
technique(s) immunoprecipitation (IP): suitable, western blot: suitable, indirect ELISA: suitable	technique(s) western blot: suitable	technique(s) indirect ELISA: suitable, western blot: 1-5 μg/mL	technique(s) immunohistochemistry: 1:50- 1:200
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C

Still not finding the right product?

Explore all of our products under Anti-CX3CL1 antibody produced in rabbit

— or —

Try our Product Selector Tool to narrow your options

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

20999903

20999902

2099-9902

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Evaluation of inter-batch differences in stem-cell derived neurons.

Gladys Morrison et al.

Stem cell research, 16(1), 140-148 (2016-01-17)

Differentiated cells retain the genetic information of the donor but the extent to which phenotypic differences between donors or batches of differentiated cells are explained by variation introduced during the differentiation process is not fully understood. In this study, we

Fractalkine Promotes Human Monocyte Survival via a Reduction in Oxidative Stress

Gemma E White

Arteriosclerosis, Thrombosis, and Vascular Biology, 34(12), 2554?2562-2554?2562 (2014)

Global Trade Item Number

SKU	GTIN
SBP2099-0.05MG	04061832165417
PRS2099-100UG	04061832509181

Questions

Reviews

No rating value