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C6852

L-Cysteine hydrochloride monohydrate

98.5-101.0% dry basis, suitable for cell culture, non-animal source, meets EP, USP testing specifications

Synonym(s):

L-Cysteine hydrochloride hydrate (1:1:1)

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25 g
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$73.80
100 g
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$222.00
1 kg
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$1,170.00

About This Item

Linear Formula:
HSCH2CH(NH2)COOH · HCl · H2O
CAS Number:
7048-04-6
Molecular Weight:
175.63
NACRES:
NA.26
PubChem Substance ID:
24892902
eCl@ss:
32160406
UNSPSC Code:
12352209
EC Number:
200-157-7
MDL number:
MFCD00065606
Beilstein/REAXYS Number:
5158059

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Product Name

L-Cysteine hydrochloride monohydrate, from non-animal source, suitable for cell culture, meets EP, USP testing specifications

biological source

non-animal source

Quality Level

300

agency

meets EP testing specifications, meets USP testing specifications

assay

98.5-101.0% dry basis

form

powder or crystals

optical activity

[α]20/D 6.1 to 7.8°, c = 8 in 1 M HCl, [α]25/D 5.7 to 6.8°, c = 8 in HCl (6 N)

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

color

white

solubility

water: 1 g/10 mL, clear, colorless

cation traces

Fe: ≤10 ppm, NH4+: ≤0.02%

application(s)

pharmaceutical (small molecule)

functional group

(sulfhydryl)

storage temp.

room temp

SMILES string

O.Cl.N[C@@H](CS)C(O)=O

InChI

1S/C3H7NO2S.ClH.H2O/c4-2(1-7)3(5)6;;/h2,7H,1,4H2,(H,5,6);1H;1H2/t2-;;/m0../s1

InChI key

QIJRTFXNRTXDIP-JIZZDEOASA-N

General description

L-Cysteine hydrochloride, commonly referred to as Cysteine HCl, is a vital component in biochemical research due to its versatile roles. Derived from the naturally occurring amino acid L-cysteine, this compound plays a crucial part in redox reactions, protein structure, cell culture, and antioxidant activity. Cysteine HCl functions as a reducing agent and a nucleophile in redox reactions. Additionally, it serves as a precursor to glutathione, a potent cellular antioxidant. Its significance extends to protein structure, where it contributes to the formation of disulfide bonds that stabilize protein structures. Cysteine HCl also supports cell growth and viability in cell culture applications. Its widespread applications encompass diverse areas of biochemical research, including redox biology, protein biochemistry, cell biology, and antioxidant investigations.

Application

L-Cysteine hydrochloride monohydrate has been used as a component of yeast dropout media for culturing yeasts. It has also been used as a component of differential reinforced clostridial broth (DRCM) for the isolation of clostridia.

Biochem/physiol Actions

Cysteine (Cys) is a sulfur-containing amino acid that modulates metabolism for growth, reproduction and immunity. It provides the disulfide linkage in proteins and in involved in the transport of sulfur. Cysteine is involved in the formation of hydrogen sulfide that functions as a signaling molecule. Cys residues are present at the catalytic sites of various enzymes.
NMDA glutamatergic receptor antagonist.

Features and Benefits

  • Suitable for Cell Culture and Biochemical research
  • High-quality compound suitable for multiple research applications

Other Notes

For additional information on our range of Biochemicals, please complete this form.

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This Item
PHR110230122C3290000
L-Cysteine hydrochloride monohydrate from non-animal source, suitable for cell culture, meets EP, USP testing specifications

Sigma-Aldrich

C6852

L-Cysteine hydrochloride monohydrate

L-Cysteine hydrochloride monohydrate Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR1102

L-Cysteine hydrochloride monohydrate

L-Cysteine hydrochloride monohydrate tested according to Ph. Eur.

Sigma-Aldrich

30122

L-Cysteine hydrochloride monohydrate

Cysteine hydrochloride monohydrate European Pharmacopoeia (EP) Reference Standard

C3290000

Cysteine hydrochloride monohydrate

form

powder or crystals

form

-

form

solid

form

-

technique(s)

cell culture | mammalian: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

technique(s)

-

assay

98.5-101.0% dry basis

assay

-

assay

98.5-101.0%

assay

-

functional group

(sulfhydryl)

functional group

-

functional group

-

functional group

-

storage temp.

room temp

storage temp.

2-30°C

storage temp.

-

storage temp.

-

color

white

color

-

color

-

color

-

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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
0000551559
0000551560
0000550702
0000551558
0000533569

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Articles

L-Cysteine in Cell Culture

Importance and uses of cysteine in serum-free eukaryotic, including hybridoma and Chinese Hamster Ovary (CHO) cell, cultures

Dietary Antioxidants

Antioxidants protect biological systems from oxidative damage produced by oxygen-containing free radicals and from redoxactive transition metal ions such as iron, copper, and cadmium.

Protocol for the selection of single-domain antibody
fragments by third generation intracellular
antibody capture
Tomoyuki Tanaka & Terence H Rabbitts
Nature (2009)
Richard S. Lord, J. Alexander Bralley
Laboratory Evaluations for Integrative and Functional Medicine (2008)
Salma Alavi et al.
STAR protocols, 1(3), 100200-100200 (2020-12-31)
The gut microbiome plays an important role in the exclusion of pathogens and, thus, infection outcomes. Microbiome-pathogen interaction studies are complicated by a lack of tractable animal models and differences in animal model versus human microbiomes. We have adapted the
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Global Trade Item Number

SKUGTIN
C6852-1KG04061833511619
C6852-25G04061835521715
C6852-100G04061835543472

Questions

1–2 of 2 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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