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718742
BrettPhos
98%, solid
Synonym(s):
2-(Dicyclohexylphosphino)3,6-dimethoxy-2′,4′,6′-triisopropyl-1,1′-biphenyl
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 mg | Please contact Customer Service for Availability | $53.30 $39.97 | |
| 500 mg | Please contact Customer Service for Availability | $147.00 $110.25 | |
| 1 g | Please contact Customer Service for Availability | $284.00 | |
| 5 g | Please contact Customer Service for Availability | $1,180.00 | |
| 25 g | Please contact Customer Service for Availability | $3,000.00 |
About This Item
Product Name
BrettPhos, 98%
Quality Level
product line
Buchwald Ligand
assay
98%
form
solid
reaction suitability
reaction type: Cross Couplings, reagent type: ligand
reaction type: Buchwald-Hartwig Cross Coupling Reaction, reagent type: ligand
reaction type: Fluorinations
greener alternative product score
old score: 8
new score: 1
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mp
187-195 °C
functional group
phosphine
greener alternative category
SMILES string
COc1c(P(C2CCCCC2)C3CCCCC3)c(c4c(C(C)C)cc(C(C)C)cc4C(C)C)c(OC)cc1
InChI
1S/C35H53O2P/c1-23(2)26-21-29(24(3)4)33(30(22-26)25(5)6)34-31(36-7)19-20-32(37-8)35(34)38(27-15-11-9-12-16-27)28-17-13-10-14-18-28/h19-25,27-28H,9-18H2,1-8H3
InChI key
WDVGNXKCFBOKDF-UHFFFAOYSA-N
General description
Application
It can be used in:
- palladium-catalyzed trifluoromethylation of aryl chlorides
- Buchwald-Hartwig amination
- synthesis of 4-aryl and alkyl substituted, N6-alkylated pyridazine-3,6-diamines via a Buchwald protocol
Features and Benefits
- White crystalline solid
- Air- and moisture-stable
- Thermally stable
- Highly efficient
- Wide functional group tolerance
- Excellent selectivity and conversion
1 of 1
This Item | |||
|---|---|---|---|
| assay 98% | assay 98% | assay 98% | assay 98% |
| reaction suitability reaction type: Cross Couplings, reagent type: ligand | reaction suitability reaction type: Cross Couplings, reagent type: ligand | reaction suitability reaction type: Cross Couplings, reagent type: ligand | reaction suitability reaction type: Cross Couplings, reagent type: ligand |
| functional group phosphine | functional group phosphine | functional group phosphine | functional group phosphine |
| form solid | form solid | form - | form solid |
| Quality Level 300 | Quality Level 300 | Quality Level 300 | Quality Level 300 |
| mp 187-195 °C | mp 123-126 °C | mp 187-190 °C (lit.) | mp 148-151 °C (lit.) |
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Storage Class
11 - Combustible Solids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Explore reliable, premium grade catalysis materials for your pharma or industrial project. Specialty chemicals and formulations are available in bulk quantities and volumes from a few grams to multi-metric tons with complete documentation to simplify your leap from development to commercialization.
Une boîte à outils de la réaction organique fournit des relations structure-activité permettant des réactions chimiques uniques afin de concevoir et de contrôler de façon optimale la synthèse de petites molécules.
The Buchwald group has developed a series of highly active and versatile palladium precatalysts and biarylphosphine ligands used in cross-coupling reactions for the formation of C-C, C–N, C–O, C–F, C–CF3, and C–S bonds. The ligands are electron-rich, and highly tunable to provide catalyst systems with a diverse scope, high stability and reactivity. Furthermore, the new series of precatalysts are air-, moisture and thermally-stable and display good solubility in common organic solvents. The use of precatalysts ensures the efficient generation of the active catalytic species and allows one to accurately adjust the ligand:palladium ratio. The ligands, precatalysts and methodology developed in the Buchwald group are user friendly and have rendered previously difficult cross couplings reactions, much easier to achieve.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| 718742-25G | 04061832855196 |
| 718742-1G | 04061832855189 |
| 718742-500MG | 04061833239810 |
| 718742-100MG | 04061833239803 |
| 718742-5G | 04061832855202 |
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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