SRE0093
β-Glucuronidase from limpets (Patella vulgata)
aqueous solution
Synonym(s):
β-D-Glucuronide glucuronosohydrolase
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 10 mL | Please contact Customer Service for Availability | $249.00 | |
| 25 mL | Please contact Customer Service for Availability | $574.00 | |
| 50 mL | Please contact Customer Service for Availability | $1,110.00 |
About This Item
CAS Number:
UNSPSC Code:
12352204
NACRES:
NA.54
MDL number:
Recombinant:
expressed in proprietary host
Concentration:
100000-200000 units/mL
$249.00
Please contact Customer Service for Availability
recombinant
expressed in proprietary host
Quality Level
form
aqueous solution
concentration
100000-200000 units/mL
shipped in
ambient
storage temp.
2-8°C
Application
New Technical Article Comparing Performance of Different Enzymes
Learn more about recent application data generated by Sigma R&D to optimize hydrolysis for different drug classes using enzymes from different sources and the use of a chromatographicaly purified enzyme to reduce the effect of esterase activity resulting in conversion of 6-MAM to Morphine
Learn more about recent application data generated by Sigma R&D to optimize hydrolysis for different drug classes using enzymes from different sources and the use of a chromatographicaly purified enzyme to reduce the effect of esterase activity resulting in conversion of 6-MAM to Morphine
More on the suitability of this product for hydrolysis of different drug-glucuronide substrates is available at this page.
Poster presentation comparing the hydrolysis efficiency of novel beta-glucuronidase enzymes from recombinant limpet and recombinant E. coli sources, click at the following poster link: Hydrolysis Efficiency Evaluation of Novel Recombinant Limpet and E. coli Beta-Glucuronidase Enzymes
The enzyme from patella vulgata is reported to be more effective in hydrolyzing opioid-glucuronides than the Helix pomatia, bovine liver and E. coli enzymes
Features and Benefits
Recombinantly expressed and purified to eliminate MAM esterase activity (6-Monoacetylmorphine→morphine). Representative analysis at high enzyme titer (50 un/μL β-glucuronidase) was less than 1% conversion of 6-MAM to morphine after 4 hours at 60 °C.
Physical form
Supplied as a solution in 100mM potassium acetate pH 5.2. It is free of detergents, carbohydrates or any other components that may interfere with sample preparation and analysis.
Other Notes
One Sigma or modified Fishman unit will liberate 1.0 μg of phenolphthalein from phenolphthalein glucuronide per hr at 37 °C at pH 3.8 (30 min assay).
1 of 1
This Item | |||
|---|---|---|---|
| concentration 100000-200000 units/mL | concentration - | concentration - | concentration - |
| form aqueous solution | form aqueous solution | form lyophilized powder | form aqueous solution |
| recombinant expressed in proprietary host | recombinant - | recombinant - | recombinant - |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. 2-8°C |
| shipped in ambient | shipped in - | shipped in wet ice | shipped in wet ice |
| Quality Level 300 | Quality Level 200 | Quality Level 300 | Quality Level 200 |
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Storage Class
10 - Combustible liquids
wgk
nwg
flash_point_f
Not applicable
flash_point_c
Not applicable
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Articles
β-glucuronidase (GUS) enzymes are utilized to hydrolyze glucuronide (gluc) drug metabolites to the parent drug, facilitating analysis by LC-MS/MS.
Global Trade Item Number
| SKU | GTIN |
|---|---|
| SRE0093-10ML | 04061831169362 |
| SRE0093-25ML | 04061831169379 |
| SRE0093-50ML | 04061831169386 |