Effects of chlordiazepoxide (CDP) and ethanolamine-O-sulphate (EOS) alone and in combination were tested on the acquisition and performance of continuous reinforcement - time out (CR-TO) and variable interval reinforcement - time out (VI-TO) operant discriminations in rats. CDP disrupted acquisition
Two "suicide" inhibitors of GABA-aminotransferase which are known to raise the concentration of GABA in vivo and to have anti-convulsant properties, have been compared for the extent to which they produce micro-vacuoles in the brains of rats. The compounds gamma-vinyl-GABA
British journal of pharmacology, 91(3), 617-625 (1987-07-01)
Slice preparations of rat cuneate nucleus were used for studies on the gamma-aminobutyric acid GABAA-receptor complex following chronic and acute pretreatment with GABA-alpha-ketoglutarate aminotransferase (GABA-T) inhibitors. The whole brain GABA concentration was significantly increased 2.9 fold and 2.6 fold following
Pharmacology, biochemistry, and behavior, 24(4), 1065-1070 (1986-04-01)
Drugs affecting the GABAergic transmission were injected into the medial preoptic anterior hypothalamic area (MPOA) and the masculine sexual behavior analyzed. Antagonizing GABAergic neurotransmission by (+) bicuculline methiodide (30 ng/cannula), or 3-mercaptopropionic acid (10 or 20 micrograms/cannula) resulted in a
1. Oral administration of the GABA transaminase inhibitor ethanolamine-O-sulphate (EOS, 5 mg/ml in drinking water) to rats for 14 days suppressed food intake by 24%, but reduced weight gain by over 35%. 2. Thus, feed efficiency (g gain/MJ eaten) was
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