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重要文件

1396309

USP

二甲双胍 盐酸盐

United States Pharmacopeia (USP) Reference Standard

同義詞:

1,1-二甲双胍 盐酸盐, 盐酸二甲双胍

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About This Item

線性公式:
NH2C(=NH)NHC(=NH)N(CH3)2 · HCl
CAS號碼:
分子量::
165.62
MDL號碼:
分類程式碼代碼:
41116107
PubChem物質ID:
NACRES:
NA.24
暫時無法取得訂價和供貨情況

等級

pharmaceutical primary standard

API 家族

metformin

製造商/商標名

USP

mp

223-226 °C (lit.)

應用

pharmaceutical (small molecule)

形式

neat

SMILES 字串

Cl[H].CN(C)C(=N)NC(N)=N

InChI

1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H

InChI 密鑰

OETHQSJEHLVLGH-UHFFFAOYSA-N

基因資訊

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一般說明

本品按现行药典规定交付。所有为支持本产品而提供的信息,包括SDS和任何产品信息单均由药典颁发机构制定并发布。如需进一步信息和支持,请访问现行药典网站。

應用

盐酸二甲双胍USP 参考标准品用于指定质量测试和分析。

还可用于制备标准、混合标准储备溶液和系统适用性溶液,用于根据以下美国药典(USP)各论进行测定、杂质分析和性能测试:
  • 盐酸二甲双胍[1]
  • 匹格列酮和盐酸二甲双胍片[2]
  • 盐酸二甲双胍片[3]
  • 格列本脲和盐酸二甲双胍片 [4]

生化/生理作用

二甲双胍是一种降糖药,可以降低血糖水平,提高胰岛素敏感性。 它的代谢作用,包括抑制肝脏糖异生,至少部分是通过激活LKB1-AMPK(AMP活化蛋白激酶)通路介导的。 这一通路的激活也参与了二甲双胍在癌细胞系中的抗增殖和促凋亡作用。

分析報告

这些产品仅供测试和化验使用。它们不适用于人类或动物,也不能用于诊断、治疗或治愈任何类型的疾病。

其他說明

可能适用相应的销售限制。

象形圖

Exclamation mark

訊號詞

Warning

危險聲明

危險分類

Acute Tox. 4 Oral - Eye Irrit. 2

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 1

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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分析證明 (COA)

Lot/Batch Number

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存取文件庫

Determination of metformin in human plasma by high-performance liquid chromatography with spectrophotometric detection
Cheng CL and Chou CH
Journal of Chromatography. B, Biomedical Sciences and Applications, 762(1), 51-58 (2001)
Development and validation of a stability indicating capillary electrophoresis method for the determination of metformin hydrochloride in tablets
Hamdan II, et al.
Journal of Pharmaceutical and Biomedical Analysis, 53(5), 1254-1257 (2010)
Pioglitazone and Metformin Hydrochloride Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 42(4), 3558-3558 (2020)
Metformin Hydrochloride Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 40(4), 2822-2822 (2020)
Glyburide and Metformin Hydrochloride Tablets
United States Pharmacopeia and National Formulary
United States Pharmacopeia, 41(2), 2128-2128 (2021)

Questions

1–2 of 2 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

      Helpful?

  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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