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重要文件

U1128

Sigma-Aldrich

尿嘧啶

BioReagent, suitable for cell culture

同義詞:

2,4(1H,3H)-嘧啶二酮, 2,4-二羟基嘧啶, 灭胞素

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About This Item

經驗公式(希爾表示法):
C4H4N2O2
CAS號碼:
分子量::
112.09
Beilstein:
507828
EC號碼:
MDL號碼:
分類程式碼代碼:
12352207
PubChem物質ID:
NACRES:
NA.75
暫時無法取得訂價和供貨情況

生物源

synthetic (organic)

品質等級

產品線

BioReagent

化驗

≥99% (HPLC)

形狀

powder

技術

cell culture | mammalian: suitable

mp

>300 °C (lit.)

溶解度

1 M NaOH: 50 mg/mL, clear to slightly hazy, colorless to faintly yellow

儲存溫度

room temp

SMILES 字串

O=C1NC=CC(=O)N1

InChI

1S/C4H4N2O2/c7-3-1-2-5-4(8)6-3/h1-2H,(H2,5,6,7,8)

InChI 密鑰

ISAKRJDGNUQOIC-UHFFFAOYSA-N

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一般說明

尿嘧啶属于嘧啶碱基家族。它是天然存在的,是RNA重要而活跃的一部分。[1]

應用

尿嘧啶已用作完全合成培养基1×、合成完全葡萄糖基酵母培养基(SC)[2]和酵母提取物(YES)培养基的补充物,用于培养酵母细胞。[3]

生化/生理作用

尿嘧啶及其衍生物在合成癌症、病毒感染、常染色体隐性遗传病、甲状腺和糖尿病药物的药物化学中不可或缺。[1]

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type N95 (US)


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分析證明 (COA)

Lot/Batch Number

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存取文件庫

Deepthi Ramesh et al.
European journal of medicinal chemistry, 207, 112801-112801 (2020-09-15)
Uracil is one of the most notable pharmacophores in medicinal chemistry as the pyrimidine nucleobase forms an integral part of many commercial drugs. Though the name uracil is usually associated with cancer drugs, there are many uracil-based compounds which can
Brian T Wilhelm et al.
Nature protocols, 5(2), 255-266 (2010-02-06)
Next-generation sequencing technologies are revolutionizing genomics research. It is now possible to generate gigabase pairs of DNA sequence within a week without time-consuming cloning or massive infrastructure. This technology has recently been applied to the development of 'RNA-seq' techniques for
Sandra M Carvalho et al.
PloS one, 8(3), e58492-e58492 (2013-03-19)
Links between carbohydrate metabolism and virulence in Streptococcus pneumoniae have been recurrently established. To investigate these links further we developed a chemically defined medium (CDM) and standardized growth conditions that allowed for high growth yields of the related pneumococcal strains
Pietro Andreone et al.
Gastroenterology, 147(2), 359-365 (2014-05-14)
The interferon-free regimen of ABT-450 (a protease inhibitor), ritonavir, ombitasvir (an NS5A inhibitor), dasabuvir (a non-nucleoside polymerase inhibitor), and ribavirin has shown efficacy in patients with hepatitis C virus (HCV) genotype 1b infection-the most prevalent subgenotype worldwide. We evaluated whether
Jordan J Feld et al.
The New England journal of medicine, 370(17), 1594-1603 (2014-04-12)
The interferon-free combination of the protease inhibitor ABT-450 with ritonavir (ABT-450/r) and the NS5A inhibitor ombitasvir (also known as ABT-267) plus the nonnucleoside polymerase inhibitor dasabuvir (also known as ABT-333) and ribavirin has shown efficacy against the hepatitis C virus

Questions

  1. Is this synthesized in in vitro or acell-derived product?

    1 answer
    1. This product is a Quality Level 200. Methods of preparation are considered proprietary for products of this Quality Level. The product is listed as a synthetic, non-animal source material. See the link below to review a sample Certificate of Origin:
      https://www.sigmaaldrich.com/certificates/sapfs/PROD/sap/certificate_pdfs/COO/Q12/U1128-BULKSLCM8881.pdf

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