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重要文件

T5639

Sigma-Aldrich

替卡西林 二钠盐

同義詞:

(2S,5R,6R)-6-[[(2R)-Carboxy-3-thienylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid disodium salt

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About This Item

經驗公式(希爾表示法):
C15H14N2Na2O6S2
CAS號碼:
分子量::
428.39
MDL號碼:
分類程式碼代碼:
51282427
PubChem物質ID:
NACRES:
NA.85
暫時無法取得訂價和供貨情況

生物源

semisynthetic

形狀

powder or crystals

顏色

white to light yellow

抗生素活性譜

Gram-negative bacteria
Gram-positive bacteria

作用方式

cell wall synthesis | interferes

儲存溫度

2-8°C

SMILES 字串

[Na+].[Na+].CC1(C)S[C@@H]2[C@H](NC(=O)[C@H](C([O-])=O)c3ccsc3)C(=O)N2[C@H]1C([O-])=O

InChI

1S/C15H16N2O6S2.2Na/c1-15(2)9(14(22)23)17-11(19)8(12(17)25-15)16-10(18)7(13(20)21)6-3-4-24-5-6;;/h3-5,7-9,12H,1-2H3,(H,16,18)(H,20,21)(H,22,23);;/q;2*+1/p-2/t7-,8-,9+,12-;;/m1../s1

InChI 密鑰

ZBBCUBMBMZNEME-QBGWIPKPSA-L

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一般說明

Chemical structure: ß-lactam

應用

Ticarcillin is a semisynthetic antibiotic with a broad spectrum of bactericidal activity against many gram-positive and gram-negative aerobic and anaerobic bacteria. It is commonly used in combination with clavulanate in order to improve it′s efficacy[1]. It is used to study appropriate dosing in pediatric patients who have cystic fibrosis[2].

生化/生理作用

Ticarcillin is a β-Lactam antibiotic that prevents bacterial cell wall biosynthesis at the level of peptidogylcan cross-linking by inhibiting peptidoglycan transpeptidases. It is derived from penicillin and is similar to carbenicillin in action. Ticarcillin is susceptible to degradation by ß-lactamases[1].

包裝

1G

其他說明

β-Lactam antibiotic
Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.

儲存和穩定性

Keep container tightly closed in a dry and well-ventilated place. Moisture sensitive. Keep in a dry place.

象形圖

Health hazardExclamation mark

訊號詞

Danger

危險分類

Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3

標靶器官

Respiratory system

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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分析證明 (COA)

Lot/Batch Number

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Smoking typically begins during adolescence or early adulthood in a social context, yet the role of social context in animal models is poorly understood. The present study examined the effect of social context on acquisition of nicotine self-administration. Sixty-day-old male
R N Brogden et al.
Drugs, 20(5), 325-352 (1980-11-01)
Ticarcillin is a semisynthetic penicillin for parenteral administration. The antibacterial activity of ticarcillin is similar to that of carbenicillin except that it is two to four times more active in vitro against Pseudomonas aeruginosa, generally less active against Gram-positive cocci
Jennifer M Loftis et al.
European journal of pharmacology, 880, 173175-173175 (2020-05-18)
There are no medications that target the neurotoxic effects or reduce the use of methamphetamine. Recombinant T-cell receptor ligand (RTL) 1000 [a partial major histocompatibility complex (pMHC) class II construct with a tethered myelin peptide], addresses the neuroimmune effects of
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Optogenetics is the genetic approach for controlling cellular processes with light. It provides spatiotemporal, quantitative and reversible control over biological signaling and metabolic processes, overcoming limitations of chemically inducible systems. However, optogenetics lags in plant research because ambient light required
Müserref Tatman-Otkun et al.
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Stenotrophomonas maltophilia is inherently resistant to many antimicrobials. So far, antimicrobial susceptibility tests for S. maltophilia have not been fully standardized. The purpose of the study was to compare the susceptibility of S. maltophilia isolates against seven different antimicrobials using

Questions

  1. Is the potency indicated for T5639 (CAS 4697-14-7) to be interpreted as the potency for the free form of Ticarcillin, or is it the potency of the salt form?

    1 answer
    1. The potency of T5639 is for the free form of Ticarcillin per USP.

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