推薦產品
生物源
human
mouse
重組細胞
expressed in CHO cells
化驗
≥98% (SDS-PAGE)
形狀
lyophilized
分子量
monomer 23 kDa by calculation (IL-12a (p35))
monomer 46 kDa by calculation (Ebi3)
包裝
pkg of 5 μg
技術
activity assay: suitable
雜質
<0.06 EU/μg endotoxin, tested
顏色
white
運輸包裝
wet ice
儲存溫度
−20°C
基因資訊
mouse ... Ebi3(50498) , Il12a(16159)
一般說明
應用
生化／生理作用
外觀
从0.2 μm过滤的PBS溶液中冻干。
重構
以100 μg/mL的浓度溶于无菌PBS中。
其他說明
由Ebi3亚基（aa 23-228）和IL-12a（p35）亚基（aa 23-215）组成的小鼠IL-35复合物可通过多肽接头与人IgG1的Fc区融合。
儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
Not applicable
閃點（°C）
Not applicable
IL-35 inhibits acute graft-versus-host disease in a mouse model
Zhang X H, et al.
International Immunopharmacology, 29(2), 383-392 (2015)
Fengqin Lin et al.
Molecular immunology, 164, 28-38 (2023-11-09)
The immune system contributes to the pathophysiology of endometriosis. The role of ThGM cells, which produce granulocyte macrophage-colony-stimulating factor (GM-CSF), in the pathogenesis of endometriosis remains unknown. To analyze the features of ThGM cells in endometriosis, a mouse endometriosis model
Chen Xu et al.
Neurochemical research, 43(7), 1454-1463 (2018-06-20)
IL-35 has been identified as a novel anti-inflammatory cytokine that belongs to the IL-12 cytokine family and has been verified to play a protective role in autoimmune diseases. In this study, we investigated the protective effects of IL-35 on cerebral
IL-35 is a novel cytokine with therapeutic effects against collagen-induced arthritis through the expansion of regulatory T cells and suppression of Th17 cells.
Niedbala W
European Journal of Immunology, 37, 3021-3029 (2007)
Jinjung Choi et al.
Clinical reviews in allergy & immunology, 49(3), 327-332 (2015-01-27)
Interleukin 35 (IL-35) is the most recently identified member of the IL-12 family of cytokines and offers the potential to be a target for new therapies for autoimmune, inflammatory, and infectious diseases. Similar to other members of the IL-12 family
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