SRP6508

Haptoglobin (Phenotype 2-2) from human plasma

≥95% (SDS-PAGE)

• 同義詞: Hp 2-2
• 分類程式碼代碼: 12352202
• NACRES: NA.32

屬性

• 生物源: human plasma
• 化驗: ≥95% (SDS-PAGE)
• 形狀: lyophilized
• 分子量: 170-900 kDa
• 包裝: pkg of 1 mg
• UniProt登錄號: P00738
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• 基因資訊: human ... HP(3240)

描述

一般說明

Haptoglobin(Hp) is an acute-phase antioxidant,[1] found abundantly in the plasma[2] , and it exhibits genetic polymorphism, that results in three genotypes namely Hp 1-1, Hp 1-2, and Hp 2-2.[1] The HP gene is mapped on the human chromosome at16q22.2.[3]

應用

Haptoglobin(Phenotype 2-2) from human plasma has been used as a mature form of haptoglobinto study its effects on human liver cancer cells.[4] It has also been used inthe preparation of the radiolabeled haptoglobin-hemoglobin (Hp-Hb) complex.[5]

生化／生理作用

Haptoglobin (Hp)binds to the extra corpuscular hemoglobin in the plasma to avoid iron-mediatedoxidative tissue damage.[2] Haptoglobin2-2 (Hp 2-2) is the least effective of the three haptoglobin phenotypes inbinding free hemoglobin and therefore provides less antioxidant benefits thanHp 1-1.[6][7] Hp 2-2 is associated with renal failure, familial and post-traumatic epilepsy.[8] It isalso associated with hypertension, atherosclerosis, and coronary heart diseasesin patients with type II diabetes.[2] Individuals who are phenotype 2-2 have the lowest concentration ofhaptoglobin in plasma.[8]

外觀

Lyophilized as a salt-free solid.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable